Diabetes Care. 2005 Oct;28(10):2486-91. Links
Serum ferritin is associated with visceral fat area and subcutaneous
fat area.
Iwasaki T, Nakajima A, Yoneda M, Yamada Y, Mukasa K, Fujita K, Fujisawa
N, Wada K, Terauchi Y.
Department of EndocrinologyMetabolism, Yokohama City University
Graduate School of Medicine, 3-9 [censored], Kanazawa-ku, Yokohama
236-0004, Japan. [email hidden].
OBJECTIVE: Until now, few clinical studies have reported on the
association between the indexes of body fat distribution and serum
ferritin, an indicator of body iron stores and a putative risk factor
for insulin resistance. We investigated the association between serum
ferritin concentrations and the indexes of distribution of adipose
tissues in the body, such as the visceral fat area (VFA), the
subcutaneous fat area (SFA), and the hepatic fat content in Japanese
subjects. RESEARCH DESIGN AND METHODS: A total of 248 Japanese subjects
(127 men and 121 postmenopausal women aged 57.8 +/- 13.9 years, BMI
25.7 +/- 4.6 kg/m(2); 140 subjects with type 2 diabetes and 108
nondiabetic subjects) were evaluated. Subjects with a history of
alcohol intake were excluded from the study. We measured body height,
body weight, and serum ferritin, as well as fasting plasma glucose and
plasma insulin concentrations. We estimated insulin resistance by
homeostasis model assessment. The fat distribution was evaluated by
measuring the VFA and SFA by abdominal computed tomography at the
umbilical level. To assess the hepatic fat content, the ratio of the
computed tomography attenuation value of the liver to that of the
spleen was calculated. RESULTS: Serum ferritin was significantly
correlated with the various indexes of adiposity examined, such as the
hepatic fat content (r = -0.280, P < 0.0001), VFA (r = 0.254, P <
0.0001), SFA (r = 0.231, P = 0.0005), and homeostasis model assessment
(r = 0.286, P = 0.0008). CONCLUSIONS: This is the first report to
directly demonstrate an association between serum ferritin and VFA and
SFA. The results of this study suggest that the serum ferritin
concentration may be a useful indicator of systemic fat content and
degree of insulin resistance.
PMID: 16186284 [PubMed - in process]
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