<<snip>>
If carbonyl iron is used they are rendered highly susceptible to EAE.
<<snip>>
Am J Pathol. 2005 Jan;166(1):147-57. Links
Nitric oxide contributes to resistance of the brown norway rat to
experimental autoimmune encephalomyelitis.
Staykova MA, Paridaen JT, Cowden WB, Willenborg DO.
Neurosciences Research Unit, The Canberra Hospital, Canberra,
Australia. [email hidden].
The Brown Norway (BN) rat is reported to be resistant to the induction
of experimental autoimmune encephalomyelitis (EAE) and a number of
mechanisms have been suggested to explain this resistance. In work
reported here we provide evidence that such resistance in the BN rat
can be accounted for, at least in part, by their ability to produce
higher levels of nitric oxide (NO) than susceptible strains of rats.
Spleen cells from the BN rat make significantly more NO following in
vitro stimulation than do cells from the Lewis or PVG rat and following
in vivo immunization using complete Freund's adjuvant (CFA) the BN rat
makes substantially more NO than either susceptible strain. If carbonyl
iron is used as adjuvant in vivo there is no increase in NO levels in
the BN rat and they are rendered highly susceptible to EAE. Immunizing
with CFA simultaneously with neuroantigen and carbonyl iron drives up
NO levels and the resistance is restored. EAE produced using carbonyl
iron is characterized by extensive macrophage/microglia presence in the
central nervous system lesions of the BN rat yet the cytokine profile
in the lymph nodes does not differ from that in the EAE Lewis rats.
PMID: 15632008 [PubMed - in process]
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Tom