Quoted message said:Subject: iron / headache / migraine From: [email hidden] (doe) Date: 9/20/2003 5:07 PM
Mountain Daylight Time Message-id: <[email hidden]>
Anyone have access to the full text .. ?
Alvin E. Lake, III and Joel R. Saper Chronic headache: New advances in treatment strategies
Neurology, Sep 2002; 59: 8S - 13. ...24 There was evidence of increased iron deposition in the PAG
of both migraine and CDH patients compared with that of controls,... ...well as a positive
correlation between duration of illness and one specific measure of non-heme iron (the transverse
relaxation rate R2'😉....
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Iron imbalance in brain may cause migraine
By Will Boggs, MD
NEW YORK, Sep 28 (Reuters Health) - Abnormalities in the way the brain's pain control center handles
iron may lead to the development of migraine attacks and headaches, according to a study by Kansas
researchers.
During migraine, a portion of the brain known as the periaqueductal gray matter (PAG) may fail to
"switch on" to prevent pain, Dr. K. Michael Welch of the University of Kansas Medical Center in
Kansas City told Reuters Health.
"In migraine, a trigger such as stress activates the PAG but it does not switch on because it is
dysfunctional," he explained, "or else switches on an abnormal part."
The result? "Pain instead of no pain," according to Welch.
His team studied levels of iron in the PAG of patients with either migraine headaches or recurrent,
non-migraine headaches and compared them to levels in people without headache or migraine.
Changes in iron levels can reflect changes in the way the cells of the PAG work, the authors pointed
out. According to the report, published in a recent issue of the journal Headache, iron levels in
the PAG were significantly increased in patients with migraine and those with headache compared to
the headache-free group.
In fact, the researchers pointed out, the longer patients had experienced headaches, the higher the
iron levels in the PAG were, though iron levels at the beginning of their illness were still clearly
higher than normal.
Increased iron levels may be both a cause of migraine attacks and a result of repeated headaches,
the investigators noted.
"Thus, we believe that the increased (iron levels) in our migraine groups reflect impaired iron
(balance), possibly associated with (nerve) dysfunction or damage," the authors concluded.
"Perhaps the PAG abnormality is essential to the cause of the headache in migraine," Welch said.
"The gradual deposition of iron increases dysfunction, and headaches coalesce from episodic to
continuous."
How, then, might one minimize the damage from increased iron stores? Welch advised, "Treat episodes
quickly and prevent (attacks) whenever possible."
bron: www.reutershealth.com
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