Iron chelation / antimalarial therapy

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[Iron chelation in antimalarial therapy]

[Article in French]

Pradines B, Millet J, Henry M.

L'Unite de Parasitologie, Institut de Medecine Tropicale du Service de Sante
des Armees, Marseille, France. [email hidden]

Rapid development of significant resistance to antimalarial drugs has been

a

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major force driving research to identify and develop new compounds. A number

of

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iron(III)-chelating compounds designed for purposes other than treating

malaria

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have in vitro antimalarial activity stemming from iron deprivation or toxic
effects related to free radical release. Several of the iron(III) chelators
have been effective in animal models of plasmodial infection. Desferrioxamine
has been used successfully against both uncomplicated and severe malaria

in

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humans. Iron-chelating agents seem to be promising therapeutic adjuvants

for

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treatment of severe Plasmodium falciparum malaria infection.

Publication Types:
Review
Review, Tutorial

PMID: 12910648 [PubMed - indexed for MEDLINE]

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