Postepy Hig Med Dosw (Online). 2007;61:268-76.
[Iron-mediated dismutation of superoxide anion augments antigen-
induced allergic inflammation: effect of lactoferrin]
[Article in Polish]
Chodaczek G, Kruzel ML.
Department of Microbiology and Immunology, University of Texas Medical
Branch, Galveston, Texas, U.S.A.
Introduction: The authors previously showed that pollen grain-, pollen
grain extract-. and subpollen particle-induced allergic inflammation
in lungs and eyes is robustly augmented by their intrinsic NAD(P)H
oxidase activity. Here they sought to determine whether lactoferrin
(LF), an iron-binding protein and immune modulator, decreases allergic
inflammation induced by ragweed (Ambrosia artemisiifolia) pollen grain
extract (RWE). Material/Methods:The impact of LF on NAD(P)H oxidase in
pollen grains and reactive oxygen species (ROS) levels in vitro and in
the lungs of experimental animals was assessed by use of redox-
sensitive probes and specific inhibitors. The influence of LF on RWE-
induced allergic inflammation was determined in a mouse experimental
model of asthma. Results:The data show that the intrinsic NAD(P)H
oxidase of pollen grains generates superoxide anion (O2.-) and that LF
does not alter its enzymatic activity, as shown by nitroblue
tetrazolium and cytochrome c assays. On the other hand, LF
significantly decreased H(2).- O(2).- and lipid peroxide (4-
hydroxynoneal and malondialdehyde) levels in airway lining fluids and
lung epithelium after intranasal challenge of naive or sensitized mice
with RWE. Furthermore, a single dose of LF prevented/decreased the
abundance of the RWE-induced robust accumulation of inflammatory and
mucin-producing cells in airways and subepithelial compartments and
decreased airway hyperreactivity. Conclusion:These data suggest that
the reduced conversion of NAD(P)H oxidase-generated O(2).- into H(2).-
O(2).- and/or .OH, which in turn synergistically enhanced pollen
antigen-induced airway inflammation, is due to the iron-binding
capacity of LF. These results support the utility of LF in human
allergic inflammatory disorders.
PMID: 17507875 [PubMed - in process]
--------------------------------------------------------------------------------
Med Hypotheses. 2003 Aug;61(2):220-2. Related Articles, Links
Excess dietary iron is the root cause for increase in childhood
autism
and allergies.
Padhye U.
2990 River Meadows, Canton, Michigan 48188, USA.
Autism is a profoundly and poorly understood developmental disorder
that impairs a person's social and communication abilities. I propose
a
hypothesis that the excessive dietary iron consumed by today's
infants
is the root cause of increased cases of Autism, allergies and other
childhood diseases. Iron is a powerful immune system modulator.
Excess
iron causes hyperactive immune system. This hyperactive immune system
attacks undigested food peptides. The chemicals released during these
intense allergic reactions can damage surrounding tissue.
Neurodegeneration is caused by combination of, oxidative stress
induced
by free iron radicals and intense immune reactions. Iron chelators
have
shown beneficial results in Autism and allergies.
Publication Types:
Review
Review, Tutorial
PMID: 12888307 [PubMed - indexed for MEDLINE]
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Definition of lactoferrin :
Iron binding protein of very high affinity (Kd 10exp 19 at pH 6.4, 26
fold greater than that of transferrin) found in milk and in the
specific granules of neutrophil leucocytes.
www.ventria.com/glossary.asp
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