Age-associated Iron Accumulation in Bone: Implications for
Postmenopausal Osteoporosis and a New Target for Prevention and
Treatment by Chelation.
Liu G, Men P, Kenner GH, Miller SC
Biometals. 2006 May 11;
Iron accumulation in tissues is believed to be a characteristic of aged
humans and a risk factor for some chronic diseases. However, it is not
known whether age-associated iron accumulation is part of the
pathogenesis of postmenopausal osteoporosis that affects approximately
one out three women worldwide. Here, we confirmed that this
accumulation of iron was associated with osteopenia in ovariectomized
(OVX) rats (a model of peri- and postmenopausal osteoporosis due to
estrogen deficiency). To further investigate whether the increased iron
level plays a causal role in the onset of bone loss, we treated OVX
rats with an orally active and bone targeted chelator that prevented
iron accumulation in their skeletal tissues. The results showed that
this treatment mitigated the loss of bone mass and the deterioration of
bone micro-architecture. We also found that one possible mechanism of
the protective action of iron chelation was to significantly reduce
bone resorption. Thus, these findings provide a novel target and a
potentially useful therapeutic strategy for the prevention and
treatment of postmenopausal osteoporosis and perhaps other age-related
diseases.
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