Proc Nutr Soc. 2004 Feb;63(1):137-43. Related Articles, Links
Does diet have a role in the aetiology of rheumatoid
arthritis?
Pattison DJ, Pattison DJ, Symmons DP, Young A.
Arthritis Research Campaign Epidemiology Unit, Stopford
Building, University of Manchester, Oxford Road, Manchester
M13 9PT, UK.
Although dietary factors have been extensively studied in
many chronic diseases, the role of diet in the epidemiology
of rheumatoid arthritis (RA) has received little attention.
Fruit and vegetables and dietary antioxidants are thought to
play a protective role in the pathogenesis of CVD and some
cancers, but few studies have investigated these dietary
components in the aetiology of RA. Fish oil supplementation
has consistently been shown to have a beneficial effect on
the symptoms of established RA, but it is not known whether
the PUFA present in fish oils can reduce the risk of
developing the disease. There is evidence that RA is less
severe in the southern Mediterranean countries, such as
Italy and Greece, where oil-rich fish, fruit, vegetables and
olive oil are consumed in greater amounts than in many other
countries. Overall, the evidence for a role of diet in the
aetiology of RA is limited to a small number of
observational studies of very different designs. Recently,
it was demonstrated that lower intakes of fruit and
vegetables and dietary vitamin C are associated with an
increased risk of developing inflammatory polyarthritis in a
free-living population in Norfolk, UK. These findings
provide further evidence for a role of diet in the
development of inflammatory arthritis, although the
mechanisms involved are uncertain.
PMID: 15099410 [PubMed - in process]
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