General fitness, health and nutrition · Public discussion

Immune system / antioxidants

Started by Doe · · Last activity · 2 posts · 400 views

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General fitness, health and nutrition
Published
26 April 2004
Last activity
26 April 2004
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Doe
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  1. <<snip>> it was established that the activity of the oxidant-
    antioxidant system (OAS) correlates not only with a severity
    of the inflammatory reaction but also with a degree of
    immune disorders <<snip>>

    Which means .. low antioxidants = low immune system /
    increased immune system disturbance ..

    Vestn Ross Akad Med Nauk. 2004;(2):34-40. Related
    Articles, Links

    [In Process Citation]

    [Article in Russian]

    [No authors listed]

    On the basis of the understanding that there are common
    development mechanisms for the inflammatory and immune
    reactions it was established that the activity of the oxidant-
    antioxidant system (OAS) correlates not only with a severity
    of the inflammatory reaction but also with a degree of
    immune disorders. Such disorders were studied in patients
    with endogenous uveitis and with cancer of the esophagus or
    uterine cervix, i.e. those nosological forms, which are
    normally accompanied by OAS decompensation, which comprised
    a lower activity of primary antioxidants (superoxides of
    dismutase, catalase, lactoferrin, ceruloplasmin etc.) in
    patients with pronounced immune disorders. Moreover, a lower
    content of secondary antioxidants, like vitamin A, ascorbic
    acid and tocopherol, was registered in the blood of patients
    with immune disorders. The suppression of the antioxidant
    system was concomitant with an essentially increased level
    of lipid peroxidation in all patients. Besides, it was noted
    that there were intensifying signs of immune disorders
    primarily observed during irradiation chemotherapy. In this
    context, a clear-cut correlation was established, in
    monitoring the body immune status, between degrees of free-
    radical formation and lipid peroxidation, on the one hand,
    and an activity of detoxication-system antioxidants, on the
    other hand,. The OAS correction by direct or indirect-action
    antioxidants normally improves the clinical course of immune
    impairments. The indirect-action antioxidants, e.g.
    synthetic regulatory peptide "Imunofan", induce the
    increasing activity of primary endogenous antioxidants. An
    activation of the detoxication antioxidant system, brings
    about, in such cases, a lower content of inflammation
    mediators, a recovery of cell-immunity indices and lower
    parameters of body auto-sensitization. Finally, the
    antioxidant system in patients with chronic inflammatory or
    oncological disorders, when recovered, ensures the
    correction of cell immunity and cuts the number of auto-
    immune reactions and of other immune disturbances.

    PMID: 15101207 [PubMed - in process]

    ------------------------------------------------------------
    --------------
    ------

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  2. We can add another bit of intresting info to this. Iron
    stores are low in some autoimmune conditions where there
    is considerable inflamation. I also recall that cases
    with inflamation per se can be found with low iron stores
    not involved with immunity. It would have been
    interesting in the instances in the abstract to see iron
    levels. If iron canbe low in the situation, would using
    antioxedants to improve them cause iron levels to rise
    again into normal levels?

    Quoted message said:

    <<snip>> it was established that the activity of the oxidant-
    antioxidant system (OAS) correlates not only with a
    severity of the inflammatory reaction but also with a
    degree of immune disorders <<snip>>

    Which means .. low antioxidants = low immune system /
    increased immune system disturbance ..

    Vestn Ross Akad Med Nauk. 2004;(2):34-40. Related
    Articles, Links

    [In Process Citation]

    [Article in Russian]

    [No authors listed]

    On the basis of the understanding that there are common
    development mechanisms for the inflammatory and immune
    reactions it was established that the activity of the oxidant-
    antioxidant system (OAS) correlates not only with a
    severity of the inflammatory reaction but also with a
    degree of immune disorders. Such disorders were studied in
    patients with endogenous uveitis and with cancer of the
    esophagus or uterine cervix, i.e. those nosological forms,
    which are normally accompanied by OAS decompensation, which
    comprised a lower activity of primary antioxidants
    (superoxides of dismutase, catalase, lactoferrin,
    ceruloplasmin etc.) in patients with pronounced immune
    disorders. Moreover, a lower content of secondary
    antioxidants, like vitamin A, ascorbic acid and tocopherol,
    was registered in the blood of patients with immune
    disorders. The suppression of the antioxidant system was
    concomitant with an essentially increased level of lipid
    peroxidation in all patients. Besides, it was noted that
    there were intensifying signs of immune disorders primarily
    observed during irradiation chemotherapy. In this context,
    a clear-cut correlation was established, in monitoring the
    body immune status, between degrees of free-radical
    formation and lipid peroxidation, on the one hand, and an
    activity of detoxication-system antioxidants, on the other
    hand,. The OAS correction by direct or indirect-action
    antioxidants normally improves the clinical course of
    immune impairments. The indirect-action antioxidants, e.g.
    synthetic regulatory peptide "Imunofan", induce the
    increasing activity of primary endogenous antioxidants. An
    activation of the detoxication antioxidant system, brings
    about, in such cases, a lower content of inflammation
    mediators, a recovery of cell-immunity indices and lower
    parameters of body auto-sensitization. Finally, the
    antioxidant system in patients with chronic inflammatory or
    oncological disorders, when recovered, ensures the
    correction of cell immunity and cuts the number of auto-
    immune reactions and of other immune disturbances.

    PMID: 15101207 [PubMed - in process]

    -----------------------------------------------------------
    ---------------
    ------

    Who loves ya. Tom Jesus Was A Vegetarian!
    jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com Man Is A Herbivore!
    pages.ivillage.commanisaherbivore DEAD
    PEOPLE WALKING
    pages.ivillage.comdeadpeoplewalking

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