Hi,
Quoted message said:Quoted message said:
A 15-year old male patient was sent to me with a history
of seizures since the first months of life due to
hypocalcemia. In that occasion, a CT-scan showed
calcifications of Globum pallidum and nothing more. After
some years he stabilized (according to the mother) and in
January went to a ped Endocrino. After some exams, he
started on calcium and Mg supplements, despite a normal
PTH level. He came for a second opinion. He has a total
calcium serum level of 7 mg/dl. An i-PTH within normal
limits. I asked a second CT-scan, which shown a worse
pattern in comparison to the first scan (not only Globus
pallidus, but also some calcification in frontal lobe).
The ophtalmologist described white lines on lens,
compatible with small areas of calcification. He has no
clinical signs of neuromuscular excitability. However,
the above mentioned signs mean to me that an
hypoparathyreoidism does exist, despite the i-PTH level.
I want to recommend initiation of calcitriol. Does anyone
have a similar case? Some reports of literature describe
production of antibodies agaisnt PTH as well as to other
hormones. There are no signs of other endocrinopathies.
No nephrocalcinosis. Mg level normal, as well as
urinalysis.