<<snip>>
a selective pattern of social dysfunction, affecting the ability to
represent other people's mental states, was found.
<<snip>>
Brain. 2005 May;128(Pt 5):1082-92. Epub 2005 Mar 23. Related Articles,
Links
Cognitive and social impairments in patients with superficial
siderosis.
van Harskamp NJ, Rudge P, Cipolotti L.
Department of Neuropsychology, National Hospital for Neurology and
Neurosurgery, London, UK.
Superficial siderosis of the CNS is a rare condition, caused by
deposition of haemosiderin in the superficial layers of the CNS due to
repeated chronic subarachnoid or intraventricular haemorrhage.
Typically, the hindbrain structures, especially the cerebellum, are
most affected. There is a surprising lack of studies investigating in
detail the behavioural functioning of patients with such a condition.
In this study, we document for the first time the cognitive, social and
emotional processing of six patients with a confirmed clinical
diagnosis of superficial siderosis. They were aged between 40 and 62
years, with a mean age of 50.2 years; four were male. We administered a
comprehensive battery of general cognitive ability and social cognitive
tasks. A review of MRI was also undertaken. The findings indicate
selective cognitive impairments affecting speech production, visual
recall memory and executive functions. In addition, a selective pattern
of social dysfunction, affecting the ability to represent other
people's mental states, was found. These behavioural dysfunctions are
reported in the context of MRI-documented lesions maximally involving
the cerebellum, in particular the superior vermis, as well as the
medial and inferior frontal cortex. These results suggest that
superficial siderosis is associated with a distinct pattern of
cognitive and social impairments. They are consistent with the recently
proposed role of the cerebellum as a modulator of cognitive, social and
emotional functions.
PMID: 15788543 [PubMed - in process]
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