Asian Pac J Cancer Prev. 2005 Jan-Mar;6(1):41-7. Related Articles,
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Dietary Administration of Inositol and/or Inositol-6-phosphate Prevents
Chemically-induced Rat Hepatocarcinogenesis.
Lee HJ, Lee SA, Choi H.
Department of Food and Nutrition, Seoul National University, Seoul
151-742, Korea. [email hidden].
Chemoprevention is considered a rational strategy for dietary
approaches to prevention of cancer. Multiple lines of evidence suggest
that many of our dietary principles are able to intervene in the
multistage carcinogenesis process and phytic acid (inositol
hexaphosphate, IP6), a phytochemical present in a variety of plant
species, has been shown to prevent various cancers, including those of
the mammary gland, colon and liver. However, the mechanism of
chemoprevention by IP6 has not been fully elucidated. In the present
study, we examined the effects of inositol and/or IP6 supplementation
on rat hepatocarcinogenesis initiated by diethylnitrosamine (DEN) and
promoted by partial hepatectomy (PH). Supplementation with either
inositol or IP6, or their combination, starting one week prior to
administration of DEN, resulted in a significant decrease in both the
area and the number of placental glutathione S-transferase positive
(GST-P+) foci, a preneoplastic marker for DEN-initiated
hepatocarcinogenesis. The administration of inositol and/or IP6 in
drinking water caused marked enhancement in the glutathione
S-transferase (GST) activity. In addition, the production of
thiobarbituric acid reactive substances and the catalase activity were
significantly reduced in rats supplemented with inositol and /or IP6.
Based on these findings, it is likely that the chemopreventive effects
of inositol and/or IP6 on rat hepatocarcinogenesis initiated by DEN and
promoted by PH are associated with induction of GST activity and
suppression of lipid peroxidation.
PMID: 15780031 [PubMed - in process]
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