Quoted message said:Subject: Re: glucosamine / metal chelator
From: anon [email hidden]
Date: 3/7/2004 5:11 PM Mountain Standard Time
Message-id: <2004030719112650073%anon@anoncom>
On 2004-03-07 15:57:06 -0500, [email hidden]
(doe) said:These studies seem to tell us the mode of action of
glucosamine in
arthritis is
Quoted message said:the SAME as the mode of action of indocin or
indomethacine or .. aspirin ..
or
Quoted message said:.. tagamet or .. metal binding.
<<snip>> Glucosamine is a precursor to a molecule called
a glycosaminoglycan-this molecule is used in the
formation and repair of cartilage. Chondroitin is the
most abundant glycosaminoglycan in cartilage and is
responsible for the resiliency of cartilage. <<snip>>
tinyurl.com2be6hOpen ↗
<<snip>> These outcomes confirm the antioxidant
properties of GAGs
(glycosaminoglycans)
Quoted message said:and further support the hypothesis that these molecules
may function as
metal
Quoted message said:chelators. <<snip>>
Eh? This is a four-year-old article, basically an opinion
piece. And where was it published? I didn't think so.
Published in '03 ..
Glycoconj J. 2003 Feb;20(2):133-41. Links
Glycosaminoglycans reduce oxidative damage induced by copper
(Cu(+2)), iron (Fe(+2)) and hydrogen peroxide (H(2)O(2)) in
human fibroblast cultures.
Campo GM, D'Ascola A, Avenoso A, Campo S, Ferlazzo AM,
Micali C, Zanghi L, Calatroni A.
Department of Biochemical, Physiological and Nutritional
Sciences, School of Medicine, University of Messina,
Policlinico Universitario, 98125 Messina, Italy.
[email hidden]
Acid glycosaminoglycans (GAGs) antioxidant activity was
assessed in a fibroblast culture system by evaluating
reduction of oxidative system-induced damage.Three
different methods to induce oxidative stress in human skin
fibroblast cultures were used. In the first protocol cells
were treated with CuSO(4) plus ascorbate. In the second
experiment fibroblasts were exposed to FeSO(4) plus
ascorbate. In the third system H(2)O(2) was utilised.The
exposition of fibroblasts to each one of the three oxidant
systems caused inhibition of cell growth and cell death,
increase of lipid peroxidation evaluated by the analysis of
malondialdehyde (MDA), decrease of reduced glutathione
(GSH) and superoxide dismutase (SOD) levels, and rise of
lactate dehydrogenase activity (LDH).The treatment with
commercial GAGs at different doses showed beneficial
effects in all oxidative models. Hyaluronic acid (HA) and
chondroitin-4-sulphate (C4S) exhibited the highest
protection. However, the cells exposed to CuSO(4) plus
ascorbate and FeSO(4) plus ascorbate were better protected
by GAGs compared to those exposed to H(2)O(2).These
outcomes confirm the antioxidant properties of GAGs and
further support the hypothesis that these molecules may
function as metal chelators. Published in 2004.
PMID: 15001845 [PubMed - in process]
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