: Int J Vitam Nutr Res. 2004 Sep;74(5):313-20. Related Articles, Links
Effect of high intakes of fruit and vegetables on redox status in type
2 onset diabetes: a pilot study.
Giammarioli S, Filesi C, Vitale B, Cantagallo A, Dragoni F, Sanzini E.
Istituto Superiore di Sanita, National Centre for Food Quality and Risk
Assessment, Rome, Italy. [email hidden]
Evidence has accumulated indicating that oxidative stress may play a
key role in the etiology of diabetic complications and the protective
effects of antioxidant nutrients are a topic of intense research. The
purpose of this study was both to obtain preliminary data on the effect
of a diet high in fruit and vegetables on metabolic control and the
oxidative status of patients with type 2 onset diabetes, and to
identify the most useful biochemical parameters for future research. At
the beginning of the study all subjects were asked to follow their
usual diet and keep a seven-day food diary. Diabetic patients then
received a dietary treatment designed to ensure a daily intake of
700-1000 g of fruit and vegetables; no dietary advice was given to
controls. Dietary antioxidants, redox status markers, and parameters of
metabolic control were measured in plasma and erythrocytes before and
after the diet. Before following the diet, diabetic patients had lower
levels of ascorbic acid, beta-carotene, and
alpha-tocopherol/cholesterol ratio than controls. After the diet these
parameters increased and there was also a reduction in total
antioxidant capacity, uric acid, and malondialdehyde and a rise in
reduced glutathione accompanied by a reduction in body mass index and
cholesterol. In conclusion, a high consumption of fruit and vegetables
by diabetic patients not receiving pharmacological treatment, seems to
produce an improvement in some redox status parameters.
PMID: 15628668 [PubMed - in process]
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