Sooo .. IS .. this simply .. vegetable lecithin .. ?
<<snip>>
IP6 deserves further study in the treatment of oral cavity squamous
cell carcinoma
<<snip>>
Laryngoscope. 2007 Jun 29; [Epub ahead of print] Links
Inositol Hexaphosphate and Paclitaxel: Symbiotic Treatment of Oral
Cavity Squamous Cell Carcinoma.
Janus SC, Weurtz B, Ondrey FG.
Quoted message said:From the Department of Otolaryngology, University of Minnesota,
Minneapolis, Minnesota, U.S.A.
OBJECTIVES/HYPOTHESIS:: Nuclear factor (NF)-kappaB is an early
response gene that has been associated with head and neck squamous
cell cancer (HNSCC) progression. NF-kappaB activation is induced by
some chemotherapy agents, including paclitaxel. The activation of
this
gene can be correlated with apoptosis resistance. Inositol
hexaphosphate (IP6) is a naturally occurring polyphosphorylated
carbohydrate. NF-kappaB levels were evaluated in oral cavity HNSCC
lines after treatment with paclitaxel and IP6, alone and in
combination. Resulting levels of cell death and apoptosis were
assessed, and conclusions are drawn regarding a possible synergistic
relationship between paclitaxel and IP6. METHODS:: NF-kappaB
activation in cancer cells treated with paclitaxel and IP6, alone and
in combination, was measured by transient transfection, and results
were interpreted by luminometry. Cell proliferation of treated cells
was measured by MTT assay. Cell viability and apoptosis of cancer
cells treated with paclitaxel and IP6 combinations were quantitated
by
trypan blue staining and Caspase-Glo 3/7 assay, respectively.
RESULTS:: IP6 was observed to significantly downregulate NF-kappaB
activation in both NA and CA-9-22 oral cavity HNSCC cell lines.
Paclitaxel treatments caused increased NF-kappaB activation in the
same cell lines. IP6 was observed to mitigate paclitaxel-induced NF-
kappaB activation in the CA-9-22 cell line. IP6, when combined with
paclitaxel, reduces CA-9-22 cell proliferation, increases cell death,
and increases apoptosis, when compared with treatment with paclitaxel
alone. CONCLUSIONS:: IP6 reduces paclitaxel induced NF-kappaB
activation and increases paclitaxel-mediated cell killing and
apoptosis. As a well-tolerated and safe supplement, IP6 deserves
further study in the treatment of oral cavity squamous cell
carcinoma.
PMID: 17607147 [PubMed - as supplied by publisher]
-----------------------------------------------------------
Web definitions for Phytate
A substance found inside the husk of whole grains and cereals that
binds certain minerals making them unavailable.
www.diet-and-health.net/glossary.html - Definition in context
phytic acid: Definition and Much More from Answers.comphytic acid
( ′fīd·ik ′as·əd ) ( organic chemistry ) C 6 H 6 [OPO(OH) 2 ] 6 An
acid found in seeds of plants as the insoluble calcium magnesium salt.
www.answers.com/topic/phytic-acid - 56k - Cached - Similar pages -
Note this
-------------------------------------------------------------------------
http://neon.chem.ox.ac.uk/vrchemistry/chapter21/Page04.html
lecithin : HO-CH2CH2-N+(CH3)3,
phytic acid:C 6 H 6 [OPO(OH) 2 ] 6
------------------------------------------------------------
These guys seem to think the .. source .. OF .. phosphates .. ARE the
same.
Sooo .. theoretically .. IF .. it IS .. "those phosphate groups" ..
then .. the phosphates ARE the same and soooo .. lecithin .. vegetable
lecithin .. would BE .. the same as .. / phytic acid / phytate ..
IP6 ..
<<snip>>
Application of each of the three organic P sources (lecithin, RNA and
sodium phytate)
<<snip>>
Titre du document / Document title
Contribution of arbuscular mycorrhizal fungi to utilization of organic
sources of phosphorus by red clover in a calcareous soil
Auteur(s) / Author(s)
FENG G. (1) ; SONG Y. C. (1) ; LI X. L. (1) ; CHRISTIE P. (1 2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Plant Nutrition, College of Agricultural Resources
and Environmental Sciences, China Agricultural University, Beijing
100094, CHINE
(2) Agricultural and Environmental Science Department, Queen's
University Belfast, Newforge Lane, Belfast BT9 5PX, ROYAUME-UNI
Résumé / Abstract
A glasshouse pot experiment investigated the uptake by arbuscular
mycorrhizal (AM) fungi associated with red clover of three organic
sources of P added to a sterilized calcareous soil of low P
availability. Each pot was separated into a central compartment for
plant growth and two outer compartments for external mycelium using 30-
μm nylon mesh to restrict the roots but allow hyphal penetration.
Plants in the central compartments were inoculated with the AM fungus
Glomus versiforme and uninoculated controls were included. Plants were
harvested on three occasions: 5, 7 and 10 weeks after sowing.
Application of each of the three organic P sources (lecithin, RNA and
sodium phytate) or inorganic P (KH[2]PO[4]) at 50 mg P kg[-1] to the
outer compartments of mycorrhizal and uninoculated pots increased the
yield, P concentration and total P uptake of red clover compared with
pots to which no P was applied, with no differences among P sources in
non-mycorrhizal plants but differences observed in mycorrhizal plants
both 7 and 10 weeks after sowing suggesting differences in
availability of the four P sources to AM mycelium. The contribution of
external mycelium to plant uptake of applied P increased with time.
The three organic P sources made smaller contributions to plant P
nutrition than KH[2]PO[4] at the first and second harvests. At the
third harvest, the contribution from KH[2]PO[4] was 23%, while those
from lecithin, RNA and sodium phytate were 23, 17 and 31%,
respectively. This suggests that with the mediation of AM fungi, soil
organic P sources can make a contribution to host plant P nutrition
comparable to that of soluble orthophosphate.
Revue / Journal Title
Agriculture,ecosystems & environment. Applied soil ecology (Agric.,
ecosyst. environ., Appl. soil ecol.) ISSN 0929-1393
Source / Source
2003, vol. 22, no2, pp. 139-148 [10 page(s) (article)] (29 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Amsterdam, PAYS-BAS (1994) (Revue)
Mots-clés anglais / English Keywords
Fodder crop ; Thallophyta ; Fungi ; Phycomycetes ; Symbionte ;
Enzyme ; Hydrolases ; Esterases ; Spermatophyta ; Angiospermae ;
Dicotyledones ; Leguminosae ; Mycorrhiza ; Calcareous soils ;
Phosphoric monoester hydrolases ; Phytic acid ; RNA ;
Phosphatidylcholine ; Phosphorus Organic compounds ; Trifolium
pratense ; Endomycorrhiza ; Available nutrient ; Nutrient uptake ;
Organic fertilizer ; Phosphorus fertilization ;
Mots-clés français / French Keywords
Plante fourragère ; Thallophyta ; Fungi ; Phycomycetes ; Symbionte ;
Enzyme ; Hydrolases ; Esterases ; Spermatophyta ; Angiospermae ;
Dicotyledones ; Leguminosae ; Mycorhize ; Glomus versiforme ; Sol
calcaire ; Phosphoric monoester hydrolases ; Phytique acide ; RNA ;
Phosphatidylcholine ; Phosphore Composé organique ; Trifolium
pratense ; Endomycorhize ; Elément assimilable ; Prélèvement
nutriment ; Engrais organique ; Fertilisation phosphatée ;
Mots-clés espagnols / Spanish Keywords
Planta forrajera ; Thallophyta ; Fungi ; Phycomycetes ; Simbionte ;
Enzima ; Hydrolases ; Esterases ; Spermatophyta ; Angiospermae ;
Dicotyledones ; Leguminosae ; Micorriza ; Suelo calcáreo ; Phosphoric
monoester hydrolases ; FÃtico ácido ; RNA ; Fosfatidilcolina ; Fósforo
Compuesto orgánico ; Trifolium pratense ; Endomicorriza ; Elemento
asimilable ; Absorción nutriente ; Fertilizante orgánico ;
Fertilización fosfatada ;
Mots-clés d'auteur / Author Keywords
Trifolium pratense ; Glomus versiforme ; Lecithin ; RNA ; Sodium
phytate ; P uptake ;
Localisation / Location
INIST-CNRS, Cote INIST : 26979, 35400010747815.0040
Copyright 2006 INIST-CNRS. All rights reserved
Toute reproduction ou diffusion même partielle, par quelque procédé ou
sur tout support que ce soit, ne pourra être faite sans l'accord
préalable écrit de l'INIST-CNRS.
No part of these records may be reproduced of distributed, in any form
or by any means, without the prior written permission of INIST-CNRS.
Nº notice refdoc (ud4) : 14463004
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