I have recently updated my PT Pro from Ver 2.00 to 2.21. When I was using version 2.00, I did the calibration test and the figures I got were withing a 1% error margin. The same margin is encounter when using Ver 2.21 too.
One major difference is in my Average Power output; keeping my heart rate between 110-120 version 2.00 gave me an figure of about 167W. 2.21 now gives me a figure of 190W. For information - I use a seperate polar heart rate monitor to record this data.