DOPAMINE EPINEPHRINE NOREPINEPHRINE

Quoted message said:

From: "Joseph" [email hidden]

Quoted message said:

I would appreciate some comments on substances which can be
used to help prevent (minimize) the conversion of dopamine
to epinephrine and norepinephrine.

I'd comment that IFAIK, all three are neurotransmitters and
do not interconvert, while it entirely possible within my
limited understanding that they share a common precursor,
using three metabolic pathways to obtain.

Now, there _are_ drugs that change the _communication_
between the dopaminergic, adrenergic (ephinephrinergic), and
norephinephrinergic _systems_. At least I think there are.

And these are the psychotropic drugs, in the recreational
and pharmaceutical classes. Is this more towards what you
were writing about? Your OP was rather brief.

Group, are these three neurotransmitters? And what is the
full list of neurotransmitters, for my understanding, as
long as we're on this?

For example, the drug I take reduces inteference from the
limbic system into the cerebrum (cerebellum), lessening
things like anxiety, distractability, any racing thoughts,
or loose associations. That's helpful. But at the same time,
since the drug affects communication between the limbic
system and the frontal lobes, anhedonia worsens, with
increases in suicidality. Exercise somehow helps with that.

Only the doctor understand which "receptors" mediate
communication between systems. I certainly don't know an H5
from a hard boiled egg!

Yours,

Doug Goncz ( ftp://users.aol.com/DGoncz/ )

Read about my physics project at NVCC:
groups.google.comgroupsOpen ↗ plus
"bicycle", "fluorescent", "inverter", "flywheel",
"ultracapacitor", etc. in the search box

Dopamine converts to epinpehrine and norepinehrine when the
amydala signals off the fight or flight cascade. Comments on
addressing this from another angle then? I am surprised and
disappointed by the lack of expertise on this matter

"Joseph" <[email hidden]> wrote in message news:<[email hidden]>...

Quoted message said:

Dopamine converts to epinpehrine and norepinehrine when
the amydala signals off the fight or flight cascade.
Comments on addressing this from another angle then? I am
surprised and disappointed by the lack of expertise on
this matter

Ok, well first of all there is peripheral epi, and central
epi. I don't know if you want to really inhibit what you
think you want.

What is your ultimate goal here?

Maybe that will get a few more responses.

Quoted message said:

From: "Joseph" [email hidden]

Quoted message said:

Dopamine converts to epinpehrine and norepinehrine when the
amydala signals off the fight or flight cascade.

Quoted message said:

Dopamine converts to epinpehrine and norepinehrine when the
amydala signals off the fight or flight cascade.

After exposure to a small amount of unknown amphetmine
class compound, I developed an "overdrive" fight or flight
response. It was explained to me that the presence of
adrenaline (epinephrine) in the blood signals the release
of more of the same from the adrenal glands located over
the kidneys.

My psychiatrist at the time recommended the major
tranquilizer perphenazine for this condition, taken
twice daily, and it was helpful. Back then, I'd read the
entire monograph, I mean really scrutinize it, and I
found this gem:

"Perphenazine blocks and partially reverses the action of
epinephrine". This meant that should I develop an allergic
reaction or suffer heart failure, epinephrine administration
could slow or even stop my heart, rather than alleviate
these symtoms. I considered wearing a Med Alert bracelet. I
just carried my drug store slips in my wallet absolutely at
all times.

Now the side effects of perphenazine are substantial.
There's dry mouth and constipation and more. With 20 years
of treatment with that drug, my runaways faded, and now,
unless I'm in a difficult social situation such as " I
believe I was here first", waiting in line at the drug
store, there is no runaway. I have considered carrying 2mg
for such an event.

Moderate exercise for two to three hours is particularly
effective at using up the adrenaline in a f/f situation.
However, vigorous exercise, such as sparring or pushups,
just makes it worse. Liquid perphenazine acts quickly and in
the ER I once was reassured that if I went into runaway
they'd just say "Perphenazine Drip: Let 'er rip!" So it
seems like it can be used IV. I never needed that. I have
taken liquid perphenazine after an adrenaline runaway ( I
was trembling) with good results.

Minor tranquilizers like Klonopin or Valium have some of
this activity too, and I take Klonopin now for insomnia.
Much gentler to the system, no dry mouth or constipation,
and only the littlest hangover in the morning where
perphenazine had me groggy all morning and most of the day.

If I may ask on behalf of the group, have you ever been
exposed to any of the amphetamines, or suffered a traumatic
event, such as a car crash or terrorist event, Joseph? I
don't mean to pry.

Quoted message said:

I am surprised and disappointed by the lack of expertise on
this matter

Here in sci.med, or at your doctor's office, or in your
reading, be it internet or library?

Quoted message said:

the amydala signals off the fight or flight cascade.

I am not familiar with the multiple steps of the cascade,
only the self-releasing nature of adrenaline.

Would you give us the steps of the cascade? What happens
first? Then what after that?

Is the amygdala the origin? It is a brain structure, yes?
And under stimulation, it releases a hormone? Which hormone
is released?

Yours,

Doug Goncz ( ftp://users.aol.com/DGoncz/ )

Read about my physics project at NVCC:
groups.google.comgroupsOpen ↗ plus
"bicycle", "fluorescent", "inverter", "flywheel",
"ultracapacitor", etc. in the search box