What are the long-term effects of riding with an ill-fitting saddle, and at what point do cyclists typically start to experience the consequences of prolonged discomfort, such as numbness, pain, or even chronic injuries? Is it possible to develop a permanent condition, like bike seat neuropathy, and what preventative measures can be taken to avoid it? Are there any studies or research that provide insight into the most common types of discomfort and injuries caused by a wrong seat, and what do manufacturers and bike fitters do to address these issues? How can cyclists effectively communicate their discomfort to a bike fitter or mechanic to ensure a proper fit, and what are the most critical factors to consider when selecting a saddle that meets individual needs?