Life Sci. 2004 Jan 23;74(10):1191-1197. Links
Lethal quercetin-digoxin interaction in pigs.
[censored] YH, Chao PD, Hsiu SL, Wen KC, Hou YC.
Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan
Digoxin is a popular cardiac glycoside with very narrow therapeutic range. Quercetin is an
ubiquitous antioxidant flavonoid. Digoxin is a substrate of P-glycoprotein (P-gp), a multi-drug
efflux transporter, and quercetin was reported to be a modulator of P-gp. The aim of this study was
to investigate the effect of quercetin on the absorption and disposition of digoxin in pigs. Pigs
were orally given digoxin (0.02 mg/kg) with and without quercetin in crossover designs. The blood
was collected via jugular vein and fluorescence polarization immunoassay was used to determine the
serum concentration of digoxin. The pharmacokinetic parameters were calculated using WINNONLIN. The
paired Student's t-test was used for statistical comparison. The coadministration of 50 mg/kg
quercetin unexpectedly resulted in sudden death of two among three pigs within 30 min after digoxin
administration. The coadministration of 40 mg/kg quercetin significantly elevated the C(max) of
digoxin by 413% and increased the AUC(0-t) by 170%. The results indicated that a very serious
pharmacokinetic interaction occurred between quercetin and digoxin. The concomitant administration
of digoxin and quercetin or quercetin-containing herbs and dietary supplement should be avoided.
PMID: 14697403 [PubMed - as supplied by publisher]
--------------------------------------------------------------------------
------
Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗