Dietary modification / antioxidant concentrations in the lung



Remember .. iron and meat .. destroy .. antioxidants ..

http://tinyurl.com/8g4ur


1: Proc Nutr Soc. 2005 Nov;64(4):510-26. Links


Vitamins and respiratory disease: antioxidant micronutrients in
pulmonary health and disease.

Kelly FJ.

The lungs are continually exposed to relatively-high O2 tensions, and
as such, in comparison with other organs, they represent a unique
tissue for the damaging effects of oxidant attack. At particular times
during a lifetime this every day challenge may increase exponentially.
The first oxidative insult occurs at birth, when cells are exposed to a
sudden 5-fold increase in O2 concentration. Thereafter, the human lung,
from infancy through to old age, can be subjected to deleterious
oxidative events as a consequence of inhaling environmental pollutants
or irritants, succumbing to several pulmonary diseases (including
infant and adult respiratory distress syndromes, asthma, chronic
obstructive pulmonary disease, cystic fibrosis and cancer) and
receiving treatment for these diseases. The present paper will review
the concept that consumption of a healthy diet and the consequent
ability to establish and then maintain adequate micronutrient
antioxidant concentrations in the lung throughout life, and following
various oxidative insults, could prevent or reduce the incidence of
oxidant-mediated respiratory diseases. Furthermore, the rationale,
practicalities and complexities of boosting the antioxidant pool of the
respiratory-tract lining fluid in diseases in which oxidative stress is
actively involved, by direct application to the lung v. dietary
modification, in order to achieve a therapeutic effect will be
discussed.

PMID: 16313695 [PubMed - in process]

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