D
doe
Guest
Biofactors. 2003;18(1-4):255-64. Links
The protective and healing effects of a natural antioxidant formulation based
on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative colitis
in rats.
Korkina L, Suprun M, Petrova A, Mikhal'chik E, Luci A, De Luca C.
Department of Molecular Biology, Russian State Medical University,
Ostrovityanova 1, Moscow 117513, Russia.
Oxygen/nitrogen reactive species (ROS/RNS) are currently implicated in the
pathogenesis of ulcerative colitis, drawing attention on the potential
prophylactic and healing properties of antioxidants, scavengers, chelators. We
evaluated the possible protective/curative effects of a natural antioxidant
preparation based on Aloe vera and ubiquinol, against intestinal inflammation,
lesions, and pathological alterations of the intestinal electrophysiological
activity and motility, in a rat model of DSS-induced colitis. 5% dextrane
sulfate (DDS) (3 days), followed by 1% DSS (4 days) was administered in
drinking water. The antioxidant formulation (25 mg/kg) was delivered with a
pre-treatment protocol, or simultaneously or post-colitis induction.
Spontaneous and acetylcholine-stimulated electrical activity were impaired in
the small intestine and in distal colon, upon exposure to DSS only. Severe
inflammation occurred, with increased myeloperoxidase activity, and significant
alterations of the oxidant/antioxidant status in colonic tissue and peritoneal
cells. Lipoperoxidation, superoxide production, glutathione peroxidase and
glutathione-S-transferase activities, and reduced glutathione content
increased, whilst superoxide dismutase and catalase activities were sharply
suppressed in colon tissue. ROS/RNS formation in peritoneal cells was strongly
inhibited. Inflammation, electrical/mechanical impairment in the gut, and a
great majority of oxidative stress parameters were improved substantially by
pre-treatment with the antioxidant preparation, but not by simultaneous
administration or post-treatment.
PMID: 14695941 [PubMed - in process]
--------------------------------------------------------------------------
------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
The protective and healing effects of a natural antioxidant formulation based
on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative colitis
in rats.
Korkina L, Suprun M, Petrova A, Mikhal'chik E, Luci A, De Luca C.
Department of Molecular Biology, Russian State Medical University,
Ostrovityanova 1, Moscow 117513, Russia.
Oxygen/nitrogen reactive species (ROS/RNS) are currently implicated in the
pathogenesis of ulcerative colitis, drawing attention on the potential
prophylactic and healing properties of antioxidants, scavengers, chelators. We
evaluated the possible protective/curative effects of a natural antioxidant
preparation based on Aloe vera and ubiquinol, against intestinal inflammation,
lesions, and pathological alterations of the intestinal electrophysiological
activity and motility, in a rat model of DSS-induced colitis. 5% dextrane
sulfate (DDS) (3 days), followed by 1% DSS (4 days) was administered in
drinking water. The antioxidant formulation (25 mg/kg) was delivered with a
pre-treatment protocol, or simultaneously or post-colitis induction.
Spontaneous and acetylcholine-stimulated electrical activity were impaired in
the small intestine and in distal colon, upon exposure to DSS only. Severe
inflammation occurred, with increased myeloperoxidase activity, and significant
alterations of the oxidant/antioxidant status in colonic tissue and peritoneal
cells. Lipoperoxidation, superoxide production, glutathione peroxidase and
glutathione-S-transferase activities, and reduced glutathione content
increased, whilst superoxide dismutase and catalase activities were sharply
suppressed in colon tissue. ROS/RNS formation in peritoneal cells was strongly
inhibited. Inflammation, electrical/mechanical impairment in the gut, and a
great majority of oxidative stress parameters were improved substantially by
pre-treatment with the antioxidant preparation, but not by simultaneous
administration or post-treatment.
PMID: 14695941 [PubMed - in process]
--------------------------------------------------------------------------
------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking