Redox Rep. 2003;8(6):365-70. Related Articles, Links
Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-
uptake inhibitors.
Khanzode SD, Dakhale GN, Khanzode SS, Saoji A, Palasodkar R.
Department of Pharmacology, Government Medical College, Nagpur, India. [email hidden]
There is evidence of derangement of oxidant and antioxidant defense systems in depression. The
present study examined the effects of fluoxetine and citalopram, standard selective serotonin re-
uptake inhibitors, on lipid peroxidation, superoxide dismutase (SOD) activity and ascorbic acid
concentrations. For this, a prospective open-labeled, randomized design was utilized. Patients with
major depression (n = 62) were compared with age- and
serum SOD, serum MDA and decrease in plasma ascorbic acid levels in patients of major depression as
compared to control subjects. The trend reversed significantly after treatment with fluoxetine and
citalopram. Results indicate a greater reduction in oxidative stress with citalopram than
fluoxetine. The Hamilton Rating Scale for Depression (HRSD) score also improved with fluoxetine and
citalopram treatment. These findings indicate that major depression is associated with increased
levels of serum SOD, serum MDA and decreased levels of plasma ascorbic acid. Treatment with
fluoxetine and citalopram reversed these biochemical parameters. This study can be used as a
predictor of drug response by fluoxetine and citalopram in major depression.
PMID: 14980069 [PubMed - in process]
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