Redox Rep. 2003;8(6):365-70. Related Articles, Links
Oxidative damage and major depression: the potential antioxidant action of
selective serotonin re-uptake inhibitors.
Khanzode SD, Dakhale GN, Khanzode SS, Saoji A, Palasodkar R.
Department of Pharmacology, Government Medical College, Nagpur, India.
[email hidden]
There is evidence of derangement of oxidant and antioxidant defense systems in
depression. The present study examined the effects of fluoxetine and
citalopram, standard selective serotonin re-uptake inhibitors, on lipid
peroxidation, superoxide dismutase (SOD) activity and ascorbic acid
concentrations. For this, a prospective open-labeled, randomized design was
utilized. Patients with major depression (n = 62) were compared with age- and
sex-matched healthy volunteers (n = 40). There was a significant increase in
serum SOD, serum MDA and decrease in plasma ascorbic acid levels in patients of
major depression as compared to control subjects. The trend reversed
significantly after treatment with fluoxetine and citalopram. Results indicate
a greater reduction in oxidative stress with citalopram than fluoxetine. The
Hamilton Rating Scale for Depression (HRSD) score also improved with fluoxetine
and citalopram treatment. These findings indicate that major depression is
associated with increased levels of serum SOD, serum MDA and decreased levels
of plasma ascorbic acid. Treatment with fluoxetine and citalopram reversed
these biochemical parameters. This study can be used as a predictor of drug
response by fluoxetine and citalopram in major depression.
PMID: 14980069 [PubMed - in process]
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