CVD and insulin resistance

(Duane Storey) said:

Do any of you guys that see patients recognize that insulin resistance and cardiovascular problems
usually go hand in hand? do you ever order GTTs for you patients to see how their insulin
responds?

Absolutely, on both accounts. You might look into "prediabetes" in your studies as well. Stay on
track with this one!
--
Winning against heart attack and stroke sonoscore.comsonoscore.comOpen ↗

Duane Storey said:

Do any of you guys that see patients recognize that insulin resistance and cardiovascular problems
usually go hand in hand? do you ever order GTTs for you patients to see how their insulin
responds?

I've been following all the research for syndrome X over the years, and it still seems like most
doctors are out of date in terms of research and treatments. I went into my doctor years ago
complaining about how hard it was to lose weight -- he just measured my TSH, which came back
normal, and that was that.. only years later did I realize that I'm slightly insulin resistant --
I knocked carbs out of my diet, and 40 lbs just melted off. My cholesterol is finally optimal,
although my BP is still a tad high (130-140/80-90).

I've also read that many common ailments are related to insulin resistance -- two of these are
male pattern baldness (I read a paper in 2000 that theorized this), and PCOS (one hypothesis is
that PCOS and MPB are essentually the same). Does anyone have any observations that would
support this?

I think it's a really cool area to study, and I'm always looking at research papers on PubMed.

Duane

Look up Metabolic Syndrome (MetS) here in SMC and in PubMed, Duane.

Humbly,

Andrew

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
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Quoted message said:

Subject: Re: CVD and insulin resistance
From: "Sonos" [email hidden]
Date: 1/9/2004 11:12 AM Mountain Standard Time
Message-id: <[email hidden]>

(Duane Storey) said:

Do any of you guys that see patients recognize that insulin resistance and cardiovascular
problems usually go hand in hand? do you ever order GTTs for you patients to see how their
insulin responds?

Absolutely, on both accounts. You might look into "prediabetes" in your studies as well. Stay on
track with this one!

So is THIS .. 'prediabetes' ..?

Br J Nutr 2001 Oct;86(4):515-9

Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians.

Hua NW, Stoohs RA, Facchini FS Department of Medicine, Division of Nephrology, San Francisco General
Hospital, San Francisco, CA, USA.

The efficacy of insulin in stimulating whole-body glucose disposal (insulin sensitivity) was
quantified using direct methodology in thirty lacto-ovo vegetarians and in thirty meat-eaters. All
subjects were adult, lean (BMI <23 kg/m2), healthy and glucose tolerant. Lacto-ovo vegetarians were
more insulin sensitive than meat-eaters, with a steady-state plasma glucose (mmol/l) of 4.1 (95 %
CI 3.5, 5.0) v. 6.9 (95 % CI 5.2, 7.5; respectively. In addition, lacto-ovo vegetarians had lower
body Fe stores, as indicated by a serum ferritin concentration (microg/l) of 35 (95 % CI 21, 49)
compared with 72 (95 % CI 45, 100) for meat-eaters To test whether or not Fe status might modulate
insulin sensitivity, body Fe was lowered by phlebotomy in six male meat-eaters to levels similar to
that seen in vegetarians, with a resultant approximately 40 % enhancement of insulin-mediated
glucose disposal Our results demonstrate that lacto-ovo vegetarians are more insulin sensitive and
have lower Fe stores than meat-eaters. In addition, it seems that reduced insulin sensitivity in
meat-eaters is amenable to improvement by reducing body Fe. The latter finding is in agreement with
results from animal studies where, no matter how induced, Fe depletion consistently enhanced
glucose disposal.

PMID: 11591239, UI: 21475355

Who loves ya. Tom

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Quoted message said:

Quoted message said:

Do any of you guys that see patients recognize that insulin resistance and cardiovascular
problems usually go hand in hand? do you ever order GTTs for you patients to see how their
insulin responds?

I might comment that insulin levels are poorly standardized, but that the fasting insulin level is
the most commonly performed. Let me know if you find and studies showing GTT challenge and insulin
level; I would be interested in seeing them.

--
Winning against heart attack and stroke sonoscore.comsonoscore.comOpen ↗