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Colitis / iron aggravates inflammation

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General fitness, health and nutrition
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28 July 2005
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30 July 2005
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  1. Original post
    Email address hidden
    Archived post
    #1

    Inflamm Bowel Dis. 2005 Aug;11(8):744-748. Related Articles, Links

    Low-dose Oral Ferrous Fumarate Aggravated Intestinal Inflammation in
    Rats with DSS-Induced Colitis.

    Erichsen K, Milde AM, Arslan G, Helgeland L, Gudbrandsen OA, Ulvik RJ,
    Berge RK, Hausken T, Berstad A.

    Quoted message said:

    From the *Department of Medicine, daggerDepartment of Pathology, and


    double daggerLaboratory of Clinical Biochemistry, Haukeland University
    Hospital, Bergen, Norway; section signInstitute of Medicine and
    parallelDepartment of Biological and Medical Psychology, University of
    Bergen, Bergen, Norway; and paragraph signNational Institute of
    Nutritional and Seafood Research, Bergen, Norway.

    BACKGROUND:: Oral ferrous iron therapy may reinforce intestinal
    inflammation. One possible mechanism is by catalyzing the production of
    reactive oxygen species. We studied the effects of low-dose oral
    ferrous fumarate on intestinal inflammation and plasma redox status in
    dextran sulfate sodium (DSS)-induced colitis in rats. METHODS:: Forty
    male Wistar rats were divided into 5 groups: no intervention, sham
    gavage (distilled water), ferrous fumarate, DSS, and ferrous fumarate +
    DSS. Ferrous fumarate was dissolved in distilled water (0.60 mg Fe/kg
    per day) and administered by gavage on days 1 to 14. All rats were fed
    a standard diet. Colitis was induced by 5% DSS in drinking water on
    days 8 to 14. Rats were killed on day 16. Histologic colitis scores,
    fecal granulocyte marker protein, plasma malondialdehyde, plasma
    antioxidant vitamins, and plasma aminothiols were measured. RESULTS::
    DSS significantly increased histologic colitis scores (P < 0.001) and
    fecal granulocyte marker protein (P < 0.01). Ferrous fumarate further
    increased histologic colitis scores (P < 0.01) in DSS-induced colitis.
    DSS + ferrous fumarate decreased plasma vitamin A compared with
    controls (P < 0.01). Otherwise, no changes were seen in plasma
    malondialdehyde, plasma antioxidant vitamins, or plasma aminothiols.
    CONCLUSION:: Low-dose oral ferrous iron enhanced intestinal
    inflammation in DSS-induced colitis in rats.

    PMID: 16043990 [PubMed - as supplied by publisher]

    --------------------------------------------------------------------------------

    Who loves ya.
    Tom
    Jesus Was A Vegetarian!
    http://jesuswasavegetarian.7h.com
    Man Is A Herbivore!
    http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING
    http://pages.ivillage.com/ironjustice/deadpeoplewalking

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  2. paula
    Archived post
    #2
    Quoted post said:

    a standard diet. Colitis was induced by 5% DSS in drinking water on
    days 8 to 14.

    What I don't get, is this type of colitis the same as humans have?? See, if that
    is the case then we should have medication to heal this by now. If one knows how
    it comes about, a cure should be easy. Is that not profitable enough or so??
    Putting to many researchers out of work?? If this is not the type of colitis
    humans get, what good is this research then??
    Reminds me of he waste of PUBLIC money for research. They managed to study
    if!!!! driving in rush hour was stressful on people. DUH, ask any kid and they
    can even tell you. But no, we had to waste I believe it was $485,000 to
    scientifically "prove" that. Oh boy......
    Just thinking out loud on a glorious thursday morning

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  3. TJ
    Archived post
    #3

    Another question...Was the dosage decreased to fit the size of the mice
    or were they overloaded with a human dose. It is a fine line between
    iron being helpful and not. Individuals who have colitis (I would
    think) have problems with low iron levels anyway. I wonder about the
    use of Slow Fe? It is easier on the stomach so does that make it easier
    on the intestines or harder because that becomes the site of digestion?
    It seems like 5% is a pretty low number to be called significant.

    Report
  4. Carole Allen
    Archived post
    #4

    I take slow fe and it does not aggravate my CD...without it I am
    anemic...

    TJ said:

    Another question...Was the dosage decreased to fit the size of the mice
    or were they overloaded with a human dose. It is a fine line between
    iron being helpful and not. Individuals who have colitis (I would
    think) have problems with low iron levels anyway. I wonder about the
    use of Slow Fe? It is easier on the stomach so does that make it easier
    on the intestines or harder because that becomes the site of digestion?
    It seems like 5% is a pretty low number to be called significant.

    Report
  5. Email address hidden
    Archived post
    #5
    Quoted message said:

    Another question...Was the dosage decreased to fit the size of the mice


    or were they overloaded with a human dose. <

    We'll assume they are NOT .. stupid ..

    Below is a comparison of the AMOUNT of iron given as a .. fortificant
    ... TO .. the mice .. and the second is a .. COMMON .. fortification
    program .. in .. humans ..

    If I am not .. mistaken .. the AMOUNT of iron added to the bread /
    flour is MUCH higher than the amount given to the mouse which created
    ... inflammation ...

    So .. according to these two studies the AMOUNT of iron added to the
    flour is MUCH higher than the amount given to the mouse ... per weight
    ... and therefore would give credence to the hypothesis that .. iron ..
    fortification .. COMMON everyday .. iron fortification .. would / could
    ... BE .. the .. CAUSE .. of inflammation in the gut ..

    <<snip>>
    Ferrous fumarate was dissolved in distilled water (0.60 mg Fe/kg
    per day
    <<snip>>

    <<snip>>
    TABLE 1. Enrichment of food vehicles in Venezuela

    Nutrient

    Pre-cooked maize flour Irona (mg/kg) 50.0

    White wheat flour Irona (mg/kg) 20.0

    a. Ferrous fumarate.

    http://www.unu.edu/unupress/food/V191e/ch02.htm
    <<snip>>

    Who loves ya.
    Tom
    Jesus Was A Vegetarian!
    http://jesuswasavegetarian.7h.com
    Man Is A Herbivore!
    http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING
    http://pages.ivillage.com/ironjustice/deadpeoplewalking

    Report

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