<<snip>>
CONCLUSIONS: This study shows a significant correlation between SF /
serum ferritin / iron and the presence of IRS / insulin resistance
syndrome criteria in a large representative population
<<snip>>
Eur J Endocrinol. 2006 Feb;154(2):333-340. Links
Association between serum ferritin and the insulin resistance syndrome
in a representative population.
Wrede CE, Buettner R, Bollheimer LC, Scholmerich J, Palitzsch KD,
Hellerbrand C.
Department of Internal Medicine I, University of Regensburg, 93042
Regensburg, Germany and.
OBJECTIVE: Unexplained hepatic iron overload with increased serum
ferritin (SF) values has been associated with the insulin resistance
syndrome (IRS), defined by the presence of one or more of the following
criteria: increased body mass index (BMI), diabetes, hyperlipidemia or
hypertension. However, as yet the association between IRS and SF in a
representative population has not been investigated. METHODS: The study
subjects participated in a nationwide epidemiological survey on
metabolic disorders in the adult German population. The 1200 probands
included in this study are representative of the German population. To
eliminate major causes of secondary iron overload, 114 (9.5%) subjects
with excessive alcohol consumption and 16 (1.5%) subjects with
serological evidence for hepatitis B or C were excluded. For all
remaining 1070 probands, complete clinical data of SF, HbA1c, known
diabetes, BMI, cholesterol, high-density lipoprotein-cholesterol and
blood pressure were available. RESULTS: SF values were significantly
increased in men and women with high BMI (> 25 kg/m(2)), increased
cholesterol (> 200 mg/dl), and increased systolic (> 160 mmHg) blood
pressure, in women with diabetes, and in men with increased diastolic
(> 95 mmHg) blood pressure. Furthermore, there was a significant
correlation between the number of IRS criteria and SF. CONCLUSIONS:
This study shows a significant correlation between SF and the presence
of IRS criteria in a large representative population. Interestingly,
the severity of the IRS seems to be associated with increased SF levels
suggesting a causal connection. Further studies are required to
investigate the pathophysiological mechanism and consequences of
increased SF levels in patients with IRS.
PMID: 16452549 [PubMed - as supplied by publisher]
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