cardiovascular disease (CVD) / iron

The key point here is:

"elevated

2 percent of the population have a number over 55, the
cutoff for the above measure. While "elevated" is not
stipulated in this abstract, if it means the standard
measure this applies not to the general population but one
which has a 55 number and high ldl. A look at the full
article will be useful to see if there is a linear
relationship or a threshold. One can assume also that with
normal ldl and higher iron levels the risk is no greater for
cvd. There is a window for low and high iron risk factors,
most people are within the window.

Quoted message said:

<<snip>> iron-mediated oxidation of LDL may be a
significant factor in the progression of CVD <<snip>>

Fam Med. 2004 May;36(5):324-9. Links

The combined effect of transferrin saturation and low
density lipoprotein on mortality.

Wells BJ, Mainous AG, King DE, Gill JM, Carek PJ,
Geesey ME.

Department of Family Medicine, Medical University of South
Carolina.

BACKGROUND AND OBJECTIVES: Evidence suggests that
cardiovascular disease (CVD) is accelerated by the
oxidation of low-density lipoprotein (LDL) in the presence
of iron. This study examined whether adults with elevated
iron, as measured by transferrin saturation (TS), and
elevated LDL are at an increased risk for mortality.
METHODS: This is a cohort study of the adult US population
using the National Health and Nutrition Examination Survey
1976-1980 (NHANES
II) merged with the NHANES II Mortality Study in 1992.
Multivariate Cox regression was performed to determine
hazard ratios (HR) for CVD and all-cause mortality for
high (>55%) or low (<55%) levels of TS and high
(>160mg/dl) or low (<160mg/dl) levels of LDL. RESULTS:
An elevated LDL alone did not significantly increase
CVD mortality or all-cause mortality in the adjusted
model. Individuals with elevated LDL and elevated TS
had a statistically significant increase in both CVD
mortality and all-cause mortality (HR=5.74 and
3.53, respectively) compared to the low LDL and low TS
group. CONCLUSIONS: The results of this study indicate an
increased risk associated with the combination of
elevated LDL and elevated TS, which suggests that iron-
mediated oxidation of LDL may be a significant factor in
the progression of CVD.

PMID: 15129378 [PubMed]

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