carboxyfullerene / buckyballs

Tom, I had the honor to talk with "bucky", quite an
impressive person. He is one of my intellectual heros. Have
you read any of his books?

Quoted message said:

Subject: Re: carboxyfullerene / buckyballs

<<snip>> the potent antioxidative action of carboxyfullerene
protects the nigrostriatal dopaminergic system from iron-
induced oxidative injury <<snip>>

J Neurochem. 1999 Apr;72(4):1634-40. Related Articles, Links

Carboxyfullerene prevents iron-induced oxidative stress in
rat brain.

Lin AM, Chyi BY, [censored] SD, Yu HH, Kanakamma PP, Luh TY, Chou
CK, Ho LT.

Department of Medical Research and Education, Veterans
General Hospital-Taipei, National Yang-Ming
University, Taiwan.

Carboxyfullerene, a water-soluble carboxylic acid derivative
of a fullerene, was investigated as a protective agent
against iron-induced oxidative stress in the nigrostriatal
dopaminergic system of anesthetized rats. Intranigral
infusion of exclusive carboxyfullerene did not increase
lipid peroxidation in substantia nigra or deplete dopamine
content in striatum. Infusion of ferrous citrate (iron II)
induced degeneration of the nigrostriatal dopaminergic
system. An increase in lipid peroxidation in substantia
nigra as well as decreases in K+-evoked dopamine overflow
and dopamine content in striatum were observed 7 days after
the infusion. Co-infusion of carboxyfullerene prevented iron-
induced oxidative injury. Furthermore, tyrosine hydroxylase-
immunoreactive staining showed that carboxyfullerene
inhibited the iron-induced loss of the dopaminergic nerve
terminals in striatum. The antioxidative action of
carboxyfullerene was verified by in vitro studies.
Incubation of brain homogenates increased the formation of
the Schiff base fluorescent products of malonaldehyde, an
indicator of lipid peroxidation. Both autooxidation (without
exogenous iron) and iron-induced elevation of lipid
peroxidation of brain homogenates were suppressed by
carboxyfullerene in a dose-dependent manner. Our results
suggest that intranigral infusion of carboxyfullerene
appears to be nontoxic to the nigrostriatal dopaminergic
system. Furthermore, the potent antioxidative action of
carboxyfullerene protects the nigrostriatal dopaminergic
system from iron-induced oxidative injury.

PMID: 10098871 [PubMed - indexed for MEDLINE]

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Who loves ya. Tom

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Tom, I always thought Bucky should have gotten a nobel prize
for his work, but it didn't fit any of the cast in stone
categories easily. It is however good to see that he will
now have an immortality of a kind in the buckyball concept
as it seems to have vast promise and application.

Quoted message said:

Subject: Re: carboxyfullerene / buckyballs

<<snip>> the potent antioxidative action of carboxyfullerene
protects the nigrostriatal dopaminergic system from iron-
induced oxidative injury <<snip>>

J Neurochem. 1999 Apr;72(4):1634-40. Related Articles, Links

Carboxyfullerene prevents iron-induced oxidative stress in
rat brain.

Lin AM, Chyi BY, [censored] SD, Yu HH, Kanakamma PP, Luh TY, Chou
CK, Ho LT.

Department of Medical Research and Education, Veterans
General Hospital-Taipei, National Yang-Ming
University, Taiwan.

Carboxyfullerene, a water-soluble carboxylic acid derivative
of a fullerene, was investigated as a protective agent
against iron-induced oxidative stress in the nigrostriatal
dopaminergic system of anesthetized rats. Intranigral
infusion of exclusive carboxyfullerene did not increase
lipid peroxidation in substantia nigra or deplete dopamine
content in striatum. Infusion of ferrous citrate (iron II)
induced degeneration of the nigrostriatal dopaminergic
system. An increase in lipid peroxidation in substantia
nigra as well as decreases in K+-evoked dopamine overflow
and dopamine content in striatum were observed 7 days after
the infusion. Co-infusion of carboxyfullerene prevented iron-
induced oxidative injury. Furthermore, tyrosine hydroxylase-
immunoreactive staining showed that carboxyfullerene
inhibited the iron-induced loss of the dopaminergic nerve
terminals in striatum. The antioxidative action of
carboxyfullerene was verified by in vitro studies.
Incubation of brain homogenates increased the formation of
the Schiff base fluorescent products of malonaldehyde, an
indicator of lipid peroxidation. Both autooxidation (without
exogenous iron) and iron-induced elevation of lipid
peroxidation of brain homogenates were suppressed by
carboxyfullerene in a dose-dependent manner. Our results
suggest that intranigral infusion of carboxyfullerene
appears to be nontoxic to the nigrostriatal dopaminergic
system. Furthermore, the potent antioxidative action of
carboxyfullerene protects the nigrostriatal dopaminergic
system from iron-induced oxidative injury.

PMID: 10098871 [PubMed - indexed for MEDLINE]

------------------------------------------------------------
--------------
------

Who loves ya. Tom Jesus Was A Vegetarian!
jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗