Cannabidiol

ironjustice said:

Am J Physiol Heart Circ Physiol. 2007 Mar 23; [Epub ahead of
print]Cannabidiol attenuates high glucose-induced endothelial cell
inflammatory response and barrier disruption.Rajesh M, Mukhopadhyay P,
Batkai S, Hasko G, Liaudet L, Drel VR, Obrosova IG, Pacher P.
NIAAA, Laboratory Physiological Studies, National Institutes of
Health, Bethesda, Maryland, United States.

A non-psychoactive cannabinoid cannabidiol (CBD) has been shown to
exert potent anti-inflammatory and antioxidant effects, and has
recently been reported to lower the incidence of diabetes in non-obese
diabetic mice and preserve the blood-retinal barrier in experimental
diabetes. In this study we have investigated the effects of CBD on
high glucose (HG)-induced, mitochondrial superoxide generation, NF-
kappaB activation, nitrotyrosine formation, iNOS and adhesion
molecules ICAM-1 and VCAM-1 expression, monocyte-endothelial adhesion,
transendothelial migration of monocytes, and disruption of endothelial
barrier function in human coronary artery endothelial cells (HCAECs).
HG markedly increased mitochondrial superoxide generation (measured by
flow cytometry using MitoSOX), NF-kappaB activation, nitrotyrosine
formation, up-regulation of iNOS and adhesion molecules ICAM-1 and
VCAM-1, transendothelial migration of monocytes, and monocyte-
endothelial adhesion in HCAECs. HG also decreased endothelial barrier
function measured by increased permeability and diminished expression
of VE-Cadherin in HCAECs. Remarkably, all the above mentioned effects
of HG were attenuated by CBD pretreatment. Since disruption of the
endothelial function and integrity by high glucose is a crucial early
event underlying the development of various diabetic complications,
our results suggest that CBD, which has recently been approved for the
treatment of inflammation, pain and spasticity associated with
multiple sclerosis in humans, may be of significant therapeutic
benefits against diabetic complications and atherosclerosis. Key
words: vascular, inflammation, oxidative stress, peroxynitrite,
cannabidiol.

PMID: 17384130 [PubMed - as supplied by publisher]

Who loves ya.
Tom

Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com

Man Is A Herbivore!http://tinyurl.com/a3cc3

DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

You have to wonder if the psychoactiver version does the same thing!
Too bad no reputable scientist could get funding to try it.
www.fibroinfoservice.com

check out ''project CUPID'' from the UK.

Cannabinoidal Use by Persons with Inflammatory brain Disease

it finished its first phase double blind placebo controlled study, with good
results,,, that spurred on this next phase drug trial test.

i have posted the url here last year,, but cant find it now,,, google if ya
like,, ''project cupid'' have a look see.

Canada used to have a medical pot drug trial going on its 4th year,, but our
wonderful right wingnut Conservative government just cut off 4 billion in
programs, one of them was this important drug study on marijuana and MS
pain.

its 3 year result gave great results ,, but why did our Effed up government
=-up and cancell this study???

they also cancelled and closed many ''womens centers'' across Canada. in
this dumbassed money grab,,,cutting social services that are important to
canadians.

isolating the pertinent Cannabinoids is very important,,,

if you visit my website www.thehighercause.com

you can have a look at a REAL marijuana Chromatic spectrum of the medical
marijuana i grow.

it lists a few Cannabinoids, THC CBD levels,, good marijuana may have a
high THC value,, but for it to benefit ME,, i need to also have a very high
level of CBD in my pot,,, up near 9-10% the CBD's do not make you
stoned/high byt provide effective relief from MS,,,

i would like a concentrated capsule of JUST CBD's as a medication tailored
to people with MS,, never get stoned,, but get the benefits fine tunedfor
me!!!!!

cheers
bobbyD

my thc levels are at their highest - 26% THC,,

"Sleepsearch" <[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

ironjustice said:

Am J Physiol Heart Circ Physiol. 2007 Mar 23; [Epub ahead of
print]Cannabidiol attenuates high glucose-induced endothelial cell
inflammatory response and barrier disruption.Rajesh M, Mukhopadhyay P,
Batkai S, Hasko G, Liaudet L, Drel VR, Obrosova IG, Pacher P.
NIAAA, Laboratory Physiological Studies, National Institutes of
Health, Bethesda, Maryland, United States.

A non-psychoactive cannabinoid cannabidiol (CBD) has been shown to
exert potent anti-inflammatory and antioxidant effects, and has
recently been reported to lower the incidence of diabetes in non-obese
diabetic mice and preserve the blood-retinal barrier in experimental
diabetes. In this study we have investigated the effects of CBD on
high glucose (HG)-induced, mitochondrial superoxide generation, NF-
kappaB activation, nitrotyrosine formation, iNOS and adhesion
molecules ICAM-1 and VCAM-1 expression, monocyte-endothelial adhesion,
transendothelial migration of monocytes, and disruption of endothelial
barrier function in human coronary artery endothelial cells (HCAECs).
HG markedly increased mitochondrial superoxide generation (measured by
flow cytometry using MitoSOX), NF-kappaB activation, nitrotyrosine
formation, up-regulation of iNOS and adhesion molecules ICAM-1 and
VCAM-1, transendothelial migration of monocytes, and monocyte-
endothelial adhesion in HCAECs. HG also decreased endothelial barrier
function measured by increased permeability and diminished expression
of VE-Cadherin in HCAECs. Remarkably, all the above mentioned effects
of HG were attenuated by CBD pretreatment. Since disruption of the
endothelial function and integrity by high glucose is a crucial early
event underlying the development of various diabetic complications,
our results suggest that CBD, which has recently been approved for the
treatment of inflammation, pain and spasticity associated with
multiple sclerosis in humans, may be of significant therapeutic
benefits against diabetic complications and atherosclerosis. Key
words: vascular, inflammation, oxidative stress, peroxynitrite,
cannabidiol.

PMID: 17384130 [PubMed - as supplied by publisher]

Who loves ya.
Tom

Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com

Man Is A Herbivore!http://tinyurl.com/a3cc3

DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

You have to wonder if the psychoactiver version does the same thing!
Too bad no reputable scientist could get funding to try it.
www.fibroinfoservice.com

THC does have a similiar effect, in this context mediated via the CB 2
receptor.Cannabinoids have long been known to have potent antoxidant and
anti-inflammatory effects. In Mole Pharmaceutics Oct 2006 there is a study
showing how cannabinoids were better or comparable to many drugs currently
used to treat alzheimers.

"Sleepsearch" <[email hidden]> wrote in message
news:[email hidden]...

Quoted message said:

ironjustice said:

Am J Physiol Heart Circ Physiol. 2007 Mar 23; [Epub ahead of
print]Cannabidiol attenuates high glucose-induced endothelial cell
inflammatory response and barrier disruption.Rajesh M, Mukhopadhyay P,
Batkai S, Hasko G, Liaudet L, Drel VR, Obrosova IG, Pacher P.
NIAAA, Laboratory Physiological Studies, National Institutes of
Health, Bethesda, Maryland, United States.

A non-psychoactive cannabinoid cannabidiol (CBD) has been shown to
exert potent anti-inflammatory and antioxidant effects, and has
recently been reported to lower the incidence of diabetes in non-obese
diabetic mice and preserve the blood-retinal barrier in experimental
diabetes. In this study we have investigated the effects of CBD on
high glucose (HG)-induced, mitochondrial superoxide generation, NF-
kappaB activation, nitrotyrosine formation, iNOS and adhesion
molecules ICAM-1 and VCAM-1 expression, monocyte-endothelial adhesion,
transendothelial migration of monocytes, and disruption of endothelial
barrier function in human coronary artery endothelial cells (HCAECs).
HG markedly increased mitochondrial superoxide generation (measured by
flow cytometry using MitoSOX), NF-kappaB activation, nitrotyrosine
formation, up-regulation of iNOS and adhesion molecules ICAM-1 and
VCAM-1, transendothelial migration of monocytes, and monocyte-
endothelial adhesion in HCAECs. HG also decreased endothelial barrier
function measured by increased permeability and diminished expression
of VE-Cadherin in HCAECs. Remarkably, all the above mentioned effects
of HG were attenuated by CBD pretreatment. Since disruption of the
endothelial function and integrity by high glucose is a crucial early
event underlying the development of various diabetic complications,
our results suggest that CBD, which has recently been approved for the
treatment of inflammation, pain and spasticity associated with
multiple sclerosis in humans, may be of significant therapeutic
benefits against diabetic complications and atherosclerosis. Key
words: vascular, inflammation, oxidative stress, peroxynitrite,
cannabidiol.

PMID: 17384130 [PubMed - as supplied by publisher]

Who loves ya.
Tom

Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com

Man Is A Herbivore!http://tinyurl.com/a3cc3

DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

You have to wonder if the psychoactiver version does the same thing!
Too bad no reputable scientist could get funding to try it.
www.fibroinfoservice.com

John H. said:

THC does have a similiar effect, in this context mediated via the CB 2
receptor.Cannabinoids have long been known to have potent antoxidant and
anti-inflammatory effects. In Mole Pharmaceutics Oct 2006 there is a study
showing how cannabinoids were better or comparable to many drugs currently
used to treat alzheimers.

"Sleepsearch" <[email hidden]> wrote in message

news:[email hidden]...

Quoted message said:

ironjustice said:

Am J Physiol Heart Circ Physiol. 2007 Mar 23; [Epub ahead of
print]Cannabidiol attenuates high glucose-induced endothelial cell
inflammatory response and barrier disruption.Rajesh M, Mukhopadhyay P,
Batkai S, Hasko G, Liaudet L, Drel VR, Obrosova IG, Pacher P.
NIAAA, Laboratory Physiological Studies, National Institutes of
Health, Bethesda, Maryland, United States.

Quoted message said:

Quoted message said:

A non-psychoactive cannabinoid cannabidiol (CBD) has been shown to
exert potent anti-inflammatory and antioxidant effects, and has
recently been reported to lower the incidence of diabetes in non-obese
diabetic mice and preserve the blood-retinal barrier in experimental
diabetes. In this study we have investigated the effects of CBD on
high glucose (HG)-induced, mitochondrial superoxide generation, NF-
kappaB activation, nitrotyrosine formation, iNOS and adhesion
molecules ICAM-1 and VCAM-1 expression, monocyte-endothelial adhesion,
transendothelial migration of monocytes, and disruption of endothelial
barrier function in human coronary artery endothelial cells (HCAECs).
HG markedly increased mitochondrial superoxide generation (measured by
flow cytometry using MitoSOX), NF-kappaB activation, nitrotyrosine
formation, up-regulation of iNOS and adhesion molecules ICAM-1 and
VCAM-1, transendothelial migration of monocytes, and monocyte-
endothelial adhesion in HCAECs. HG also decreased endothelial barrier
function measured by increased permeability and diminished expression
of VE-Cadherin in HCAECs. Remarkably, all the above mentioned effects
of HG were attenuated by CBD pretreatment. Since disruption of the
endothelial function and integrity by high glucose is a crucial early
event underlying the development of various diabetic complications,
our results suggest that CBD, which has recently been approved for the
treatment of inflammation, pain and spasticity associated with
multiple sclerosis in humans, may be of significant therapeutic
benefits against diabetic complications and atherosclerosis. Key
words: vascular, inflammation, oxidative stress, peroxynitrite,
cannabidiol.

Quoted message said:

Quoted message said:

PMID: 17384130 [PubMed - as supplied by publisher]

Quoted message said:

Quoted message said:

Who loves ya.
Tom

Quoted message said:

Quoted message said:

Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com

Quoted message said:

Quoted message said:

Man Is A Herbivore!http://tinyurl.com/a3cc3

Quoted message said:

Quoted message said:

DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

Quoted message said:

You have to wonder if the psychoactiver version does the same thing!
Too bad no reputable scientist could get funding to try it.
www.fibroinfoservice.com

This post reminds me of my young days of being a heavy pot smoker. I
remember when I had a badly congested head, that I could take my bong
and fill it up the bowl with dried large fan leaves from a plant and
wham- my sinus problem would drain fast and my headache was instantly
gone. No doubt it was a drug other than THC that made the leaves work
on my sinus problems better than smoking good bud did. CBD, CBN. or
whatever else is in pot can have real medical value. The fan leaves of
a pot plant have low THC content, however smoking them can still make
one's eyes red, and create a spacey feeling. Smoking the leaves worked
really good at draining my congested head (head colds), while the bud
did now always have this effect with me.