Bad Thing or Good Thing

"doe" <[email hidden]> wrote in message "]news:[email hidden]...

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Is this a bad or a good thing which is happening to these red blood cells? Would this increase or
decrease their stability / viability?

It is a normal thing, I would imagine. The fats available to make the cell membrane would change as
the diets change.

As far as increasing or decreasing membrane stababiltiy, I don't know. I doubt there would be that
much functional difference. I don't think the composition of the cell membrane would affect how long
the red cells last that much.

Jeff

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Biosci Biotechnol Biochem. 2003 Jul;67(7):1457-64. Related Articles,

Links

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High-cholesterol diets induce changes in lipid composition of rat

erythrocyte

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membrane including decrease in cholesterol, increase in alpha-tocopherol

and

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changes in fatty acids of phospholipids.

Mawatari S, Ohnishi Y, Kaji Y, Maruyama T, Murakami K, Tsutsui K, Fujino

T.

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Department of Nutrition and Health Science, Faculty of Human Environmental Science, [censored]
Women's University, Japan. [email hidden]

Effects of high dietary cholesterol on erythrocyte membrane lipids were studied. Feeding rats with
a diet containing 0.5% cholesterol and 0.15%

sodium

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cholate for two weeks induced changes in erythrocyte membrane lipids

including

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a decrease in cholesterol, an increase in alpha-tocopherol (alpha-Toc) and changes in the fatty
acid composition of phospholipids. Oleic acid and

linoleic

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acid increased, while arachidonic acid decreased in phosphatidylcholine. Saturated fatty acids
decreased and unsaturated fatty acids increased in phosphatidylethanolamine. Almost the same
changes in membrane lipids were

also

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noted after six weeks of feeding rats with the diet. A diet containing

.5%

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cholesterol but without sodium cholate caused a decrease in erythrocyte cholesterol and an
increase in erythrocyte alpha-Toc after two weeks of feeding, as compared to the basal diet,
indicating that high dietary cholesterol, but not sodium cholate, was responsible for these
changes in

the

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erythrocyte membrane.

PMID: 12913287 [PubMed - in process]

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Who loves ya. Tom

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