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Autism / oxidative stress

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25 June 2004
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  1. Eur Arch Psychiatry Clin Neurosci. 2004 Jun;254(3):143-147.
    Related Articles, Links

    Increased oxidative stress and altered activities of
    erythrocyte free radical scavenging enzymes in autism.

    Zoroglu SS, Armutcu F, Ozen S, Gurel A, Sivasli E, Yetkin
    O, Meram I.

    Gaziantep Typ Fakultesi, Kolejtepe Binasi Cocuk ve Ergen
    Psikiyatrisi AD, Kolejtepe, 27200, Gaziantep, Turkey,
    [email hidden]

    There is great evidence in recent years that oxygen free
    radicals play an important role in the pathophysiology of
    many neuropsychiatric disorders. The present study was
    performed to assess the changes in red blood cells
    thiobarbituric acid-reactive substances (TBARS) levels, and
    superoxide dismutase (SOD), catalase (CAT), adenosine
    deaminase (ADA) and xanthine oxidase
    (XO) activities in patients with autism (n = 27) compared
    to age- and

    levels (p < 0.001) and XO (p < 0.001) and SOD (p < 0.001)
    activity, decreased CAT (p < 0.001) activity and unchanged
    ADA activity were detected. It is proposed that antioxidant
    status may be changed in autism and this new situation may
    induce lipid peroxidation. These findings indicated a
    possible role of increased oxidative stress and altered
    enzymatic antioxidants, both of which may be relevant to the
    pathophysiology of autism.

    PMID: 15205966 [PubMed - as supplied by publisher]

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  2. Wow.

    As a schizophrenic, I experience some autism. The old "four
    A's" of schizophrenia are: autism, affect, ambivalence, and
    associations. These are replaced in modern nursing school by
    alogia, anhedonia, affect, and association.

    I am brilliantly verbal, and yet autistic. This is no
    contradiction. What happened to me caused me to give up my
    faith in language, and so develop a pattern of highly
    intellectuallized, yet ineffective speech. I swear, I can
    sit in "talk therapy" all day and share affective speech
    (emotionally honest speech) and intellectualize around it,
    but it does me no good. My speech is not substantially
    _effective_. That is, talking about my emotions doesn't
    change my life. And as for making plans with speech, that
    is, considering anything more substantial than when is my
    next appointment, I am paralyzed, mute. Yet the therapists I
    am with do not notice this. They think, he must be able to
    talk to anybody about anything, and so, doesn't need help.

    But I can't. It's as if I'm mute. I've lost the critical
    belief that language _does some good_, that's it's useful.

    So what I am looking for is a diagnosis of autism secondary
    to schizophrenia, and treatement with a speech language
    pathologist operating at a very challenging level.

    How does this sound?

    Thanks, interesting article and I will ask my psychiatrist
    to interpret it. Perhaps she can test for:

    Quoted message said:

    red blood cells thiobarbituric acid-reactive substances
    (TBARS) levels, and superoxide dismutase (SOD), catalase
    (CAT), adenosine deaminase (ADA) and xanthine oxidase
    (XO) activities

    and determine if there is

    Quoted message said:

    lipid peroxidation

    Yours,

    Doug Goncz ( ftp://users.aol.com/DGoncz/ )

    Read about my physics project at NVCC:
    groups.google.comgroups plus
    "bicycle", "fluorescent", "inverter", "flywheel",
    "ultracapacitor", etc. in the search box

  3. Quoted message said:

    Subject: Re: Autism / oxidative stress
    From: [email hidden] ( Doug Goncz )
    Date: 6/21/2004 5:00 AM Mountain Daylight Time
    Message-id: <[email hidden]>

    Wow.

    As a schizophrenic, I experience some autism. The old "four
    A's" of schizophrenia are: autism, affect, ambivalence, and
    associations. These are replaced in modern nursing school
    by alogia, anhedonia, affect, and association.

    I am brilliantly verbal, and yet autistic. This is no
    contradiction. What happened to me caused me to give up
    my faith in language, and so develop a pattern of highly
    intellectuallized, yet ineffective speech. I swear, I can
    sit in "talk therapy" all day and share affective speech
    (emotionally honest speech) and intellectualize around
    it, but it does me no good. My speech is not
    substantially _effective_. That is, talking about my
    emotions doesn't change my life. And as for making plans
    with speech, that is, considering anything more
    substantial than when is my next appointment, I am
    paralyzed, mute. Yet the therapists I am with do not
    notice this. They think, he must be able to talk to
    anybody about anything, and so, doesn't need help.

    But I can't. It's as if I'm mute. I've lost the critical
    belief that language _does some good_, that's it's useful.

    So what I am looking for is a diagnosis of autism secondary
    to schizophrenia, and treatement with a speech language
    pathologist operating at a very challenging level.

    How does this sound?

    Thanks, interesting article and I will ask my psychiatrist
    to interpret it. Perhaps she can test for:

    Quoted message said:

    red blood cells thiobarbituric acid-reactive substances
    (TBARS) levels, and superoxide dismutase (SOD), catalase
    (CAT), adenosine deaminase (ADA) and xanthine oxidase
    (XO) activities

    and determine if there is

    Quoted message said:

    lipid peroxidation


    If you have schizophrenia they have shown lipid peroxidation
    / oxidative stress TO BE involved ..

    I've questioned Dr. Hoffer as to his work with B vitamins
    and schizophrenia and pointed out to him how it is KNOWN
    iron overload induces schizophrenia and asked him whether he
    thought the B vitamins might be just simply chelating the
    iron in the body ..

    B vitamins are 'argued' to be antioxidants and this ..
    discrepency may arrive by the fact an antioxidant seems to
    be classified as a 'quencher' OF free radicals or a
    'binder/chelator' .. of .. the free radical .. creator.

    tinyurl.com2qlyl

    <<snip>> In addition to increased oxidative stress, altered
    immune function may also be responsible for increased
    phospholipase activities.

    PMID: 15006493 [PubMed - indexed for MEDLINE]

    ------------------------------------------------------------
    --------------
    ------

    Who loves ya. Tom

    Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com
    Man Is A Herbivore!
    pages.ivillage.commanisaherbivore DEAD
    PEOPLE WALKING
    pages.ivillage.comdeadpeoplewalking

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