Since lecithin is KNOWN to 'melt fat' .. would / could one
extrapolate the animal studies TO this disease ..
atherosclerosis .. ?
Thereby assuming SINCE in man .. lecithin melts fat ..
would / could the lecithin in man also melt ..
atherosclerosis .. ?
As in the mouse ..
<<snip>> dietary lecithin promotes removal of lipid from
established atherosclerotic plaque. <<snip>>
Dermatol Surg. 2004 Mar;30(3):422-7; discussion 428.
Related Articles, Links
Treatment of lower eyelid fat pads using
phosphatidylcholine: clinical trial and review.
Ablon G, Rotunda AM.
West Los Angeles Veteran Administration Medical Center, Los
Angeles, CA, USA. [email hidden]
BACKGROUND: Injectable phosphatidylcholine, a lecithin-
derived phospholipid, has been previously demonstrated to
improve the appearance of infraorbital fat pad herniation.
Current use internationally has led to a significant
interest in this novel substance. OBJECTIVE: To evaluate the
efficacy and safety of injectable phosphatidylcholine, we
conducted an open-label study for the treatment of
infraorbital fat pad herniation. METHODS: Patients received
0.4-mL phosphatidylcholine (50 mg/mL) injections within
infraorbital fat pads every 2 weeks. Patient and physician
grading of fat herniation, side effects, digital
photographs, and a follow-up questionnaire was recorded.
RESULTS: Ten of the 13 enrolled patients had three to five
treatments. Improvements in fat herniation were reported in
80% and 70% of patients as graded by the physician and
patients, respectively. Sixty percent of patients assessed
their improvement as equal or greater than 5 points (on a
10-point fat herniation scale); however, the physician
judged 40% of patients improving to this degree. Little or
no response was seen in three patients. Side effects
included burning, erythema, and swelling at the injection
site. At follow-up averaging 9 months, 50% of patients
reported persistence of benefit, 20% experienced some
fading, and 30% were the nonresponders. CONCLUSIONS:
Injectable phosphatidylcholine is a novel treatment for
infraorbital fat herniation that may benefit some patients
who are considering blepharoplasty. Larger studies
evaluating long-term safety and efficacy of
phosphatidylcholine for cosmetic purposes are warranted.
PMID: 15008874 [PubMed - in process]
------------------------------------------------------------
--------------
------
Br J Exp Pathol 1985 Feb;66(1):35-46
Hyperlipoproteinaemia and atherosclerosis in rabbits fed low-
level cholesterol and lecithin.
Hunt CE, Duncan LA Dutch-Belted rabbits were fed for 18
months an atherogenic semipurified gel diet containing 14%
hydrogenated coconut oil and 0.06% cholesterol
(approximately 0.15 mg/kcal) or a non-atherogenic basal gel
diet containing the same ingredients but with no coconut oil
or cholesterol. Rabbits fed atherogenic diet developed
hypercholesterolaemia (means 733 mg/dl at 16 months) and
plasma lipoprotein (LP) distribution shifted from a pattern
in which high-density lipoproteins (HDL) predominated to one
in which very-low-density lipoproteins (VLDL) were
predominant. Total cholesterol/triglyceride ratio in d less
than 1.006 LP changed from 0.3 to 1.8. Plasma cholesterol
and LP distribution returned to normal in rabbits fed
atherogenic diet for 18 months followed by atherogenic diet
plus 3% soya lecithin for an additional 4 months. Rabbits
fed atherogenic diet for 18 months had extensive, usually
full circumference fibromuscular plaques in main branches of
coronary arteries and all portions of aorta which
compromised lumen area by almost 50%. These lesions were
modified in rabbits fed atherogenic diet plus lecithin. The
plaques lacked foam cells and cholesterol clefts, were less
cellular with a distinct fibrous surface and occupied less
space. Animals fed basal diet did not develop
hypercholesterolaemia (means 86 mg/dl at 16 months),
although distribution of plasma LP shifted slightly in
favour of increased low-density lipoproteins
(LDL) and decreased HDL compared with rabbits fed standard
commercial diet. Basal diet rabbits had no coronary
atherosclerosis and only minimal focal foam cell
lesions in proximal aorta. Liver injury including
fatty change, cholangitis and portal fibrosis occurred
in animals fed atherogenic diet. Thus, rabbits fed
appropriate diets low in cholesterol accumulate cholesterol-
enriched LP in their plasma and develop lesions in
abdominal aorta and main branches of coronary arteries
which are similar to those in man. Also, in this
experimental model, dietary lecithin promotes a return
to normal of the LP distribution profile and removal
of lipid from established atherosclerotic plaque.
PMID: 3970829, UI: 85122459
----------------------------------------------
Who loves ya. Tom Jesus Was A Vegetarian!
jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗