Article] Stuck on an aging mitochondria

"Robert Karl Stonjek" <[email hidden]> wrote in
message "]news:[email hidden]...

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Stuck on an aging mitochondria DNA repair enzymes become trapped in the mitochondrial

membrane as the

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organelle ages By David Secko

The mitochondrial theory of aging suggests that DNA damage

in the

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mitochondrial genome leads to dysfunction and production

of reactive oxygen

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species implicated in the aging process. This DNA damage

partly results from

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mutagenic base lesions in the form of

7,8-dihydro-8-oxoguanine (8-oxoG) and

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uracil. Cells normally utilize DNA glycosylases, such an

8-oxoguannine-DNA

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glycosylase (OGG1) and uracil-DNA glycosylase (UDG), in

the first step of

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repairing such DNA damage. Aging produces high levels of

8-oxoG damage in

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mitochondrial DNA, but the levels and activity of OGG1 are

higher in

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mitochondrial extracts from older rodents. In the

September 1 PNAS, Bartosz

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Szczesny and colleagues at the University of Texas Medical

Branch show that

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this apparent inconsistency is caused by a large fraction

of OGG1 being

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caught in the mitochondrial membrane (PNAS,

DOI:10.1073/pnas.1932854100,

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September 1, 2003).

Read the rest at The Scientist.com biomedcentral.com01Open ↗

Kind Regards, Robert Karl Stonjek.

I saw this article and read it with interest. While I did not understand all of it, I found it
interesting that there is a Mitochondrial Theory of Ageing at all, and that it is considered by at
least some to be the sole, or at least primary, basis for ageing. I wonder if it is possible for the
answer to the problem of ageing to be that simple (well, not exactly simple, but at least singular.)
I suppose I doubt it, but it is nice to imagine that repairing this one problem could be the answer
to the putative Fountain of Youth. Any other feelings on this? ....tonyC