Mol Aspects Med. 2004 Feb-Apr;25(1-2):117-23. Links
Molecular bases of the treatment of Alzheimer's disease with
antioxidants: prevention of oxidative stress.
Vina J, Lloret A, Orti R, Alonso D.
Departments of Physiology, Preventive Medicine, and
Neurology, Faculty of Medicine, University of Valencia,
Avda. Blasco Ibanez 17, E-46010 Valencia, Spain.
Alzheimers's disease is associated with a systemic
oxidative stress situation which can be followed in vivo by
determining biomarkers such as plasma lipoperoxides and
TBARS levels and the oxidation degree of glutathione in red
blood cells. It has been observed that Alzheimer's patients
show an increased level of plasma TBARS, which indicates a
higher free radical oxidation of plasma unsaturated
phospholipids, and an increased oxidation of red blood
cells glutathione, which indicates oxidative stress in
peripheral cells. This latter, glutathione oxidation, was
found to correlate statistically with the cognitive status
of the patients. Treatment with vitamin E resulted in an
improved cognitive performance only of those patients in
which the tocopherol acted as an antioxidant, according to
blood indicative markers of oxidative stress. Indeed, the
effect of vitamin E on Alzheimer's disease patients showed
considerable variations both in its antioxidant function
and in its capacity to improve cognitive functions. An
important conclusion from the reported results is that
epidemiological or clinical studies that aim to test the
effect of antioxidant supplementation on given functions
should include the determination of the antioxidant status
of the patients by the measurement of blood markers of
oxidative stress.
PMID: 15051321 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD
PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗