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1: Cell Biochem Funct. 2004 Jan;22(1):53-7. Links
Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid
arthritis.
Kamanli A, Naziroglu M, Aydilek N, Hacievliyagil C.
Department of Physical Medicine and Rehabilitation, Medical Faculty, Firat
University, Elazig, Turkey.
In recent years, a great number of studies have investigated the possible role
of reactive oxygen species in the aetiology and pathogenesis of rheumatoid
arthritis (RA). The aim of this study was to investigate plasma concentrations
of vitamin E, beta-carotene, activities of glutathione peroxidase (GSH-Px) and
catalase, levels of lipid peroxidation (MDA) and reduced glutathione (GSH) in
36 patients with rheumatoid arthritis (RA) and 22 healthy age-matched controls.
The plasma activity of GSH-Px and catalase (p < 0.001), levels of GSH (p <
0.01), concentration of beta-carotene (p < 0.05) and vitamin E (p < 0.001),
haemoglobin and hematocrit (p < 0.05) were significantly lower in patients with
RA than in controls. The MDA levels (p < 0.01), C reactive protein, rheumatoid
factor, anti-streptolysin-o values (p < 0.001), platelet count (p < 0.05) and
erythrocyte sedimentation rate (p < 0.001) were higher in the patient group
than in the control group. These results provide some evidence for a potential
role of increased lipid peroxidation and decreased enzymic and non-enzymic
antioxidants in RA by its inflammatory character. These results suggested that
oxidant stress plays a very important role in the pathogenesis of RA. Copyright
2003 John Wiley & Sons, Ltd.
PMID: 14695655 [PubMed - in process]
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Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
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Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid
arthritis.
Kamanli A, Naziroglu M, Aydilek N, Hacievliyagil C.
Department of Physical Medicine and Rehabilitation, Medical Faculty, Firat
University, Elazig, Turkey.
In recent years, a great number of studies have investigated the possible role
of reactive oxygen species in the aetiology and pathogenesis of rheumatoid
arthritis (RA). The aim of this study was to investigate plasma concentrations
of vitamin E, beta-carotene, activities of glutathione peroxidase (GSH-Px) and
catalase, levels of lipid peroxidation (MDA) and reduced glutathione (GSH) in
36 patients with rheumatoid arthritis (RA) and 22 healthy age-matched controls.
The plasma activity of GSH-Px and catalase (p < 0.001), levels of GSH (p <
0.01), concentration of beta-carotene (p < 0.05) and vitamin E (p < 0.001),
haemoglobin and hematocrit (p < 0.05) were significantly lower in patients with
RA than in controls. The MDA levels (p < 0.01), C reactive protein, rheumatoid
factor, anti-streptolysin-o values (p < 0.001), platelet count (p < 0.05) and
erythrocyte sedimentation rate (p < 0.001) were higher in the patient group
than in the control group. These results provide some evidence for a potential
role of increased lipid peroxidation and decreased enzymic and non-enzymic
antioxidants in RA by its inflammatory character. These results suggested that
oxidant stress plays a very important role in the pathogenesis of RA. Copyright
2003 John Wiley & Sons, Ltd.
PMID: 14695655 [PubMed - in process]
--------------------------------------------------------------------------
------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking