Re: Why do I feel worse when taking Omega-3 supplements?



J

John Sankey

Guest
Sorry, montygram, but I too have spent some time checking out brain
chemistry, including a professional period attempting to relate brain
structures to possible computational models of human thought.

Yes, 5,8,11-eicosatrienoic acid (20:3 n-9; it's really known as
Mead's acid only in the brewing industry) is found in the brain, but
the overwhelming scientific view is that it is synthesized in the
brain only under conditions of deprivation of essential lipids (ones
we can't synthesize de-novo ourselves), especially of 20:4 n-6.

There are plenty of studies relating IQ of infants to adequate/
inadequate maternal dietary intake of long-chain n-3 and n-6 lipids
during pregnancy and lactation.

The variations among ethnic groups of the ability to lengthen short-
chain polyunsaturates is well accepted as an indication that our
nervous system developed under an adequate supply of long-chain
lipids, and that the enzymes necessary to elongate short-chain into
long-chain were selected for only when humans moved away from areas
where dietary fish supplies were ample.

20:3 n-9 may work in our brains, and dietary supplements of it may be
useful, but n-3 and n-6 are, I am certain, the natural choice for our
brain lipids. (I'll stay out of cancer-related arguments, though,
because I know almost nothing about them.)
 
On 27 Mar 2005 21:33:28 GMT, [email protected] (John Sankey)
wrote:

>
>brain only under conditions of deprivation of essential lipids (ones
>we can't synthesize de-novo ourselves), especially of 20:4 n-6.


Sorry, it is only linoleic acid and linolenic acid we cannot form
ourself (from the omega-9 acids) We don't have that desaturase, and
neither can we form linolenic acid from linoelic acid neither.

But chain elongation and further desaturations of the C18-acids, we
are capable of, like desaturating DHGLA to arachidonic acid.
 
I agree that infants may need small amounts of these otherwises
dangerous fatty acids, which explains why pregnant women crave things
like sardines. But tell me when I am going to drop dead, or even show
"deficiency" symptoms, from avoiding omega 3s and 6s, and instead
allowing my body to make the Mead acid? Also, if you go to pubmed, you
will see that the phrase "Mead acid" is used by scientists in their
studies. My grandparents do not eat oily fish, they have fairly high
omega 6 diets. No canola oil. No flax. No source of omega 3s for
decades, and they are in fairly good shape (he is in his 90s and she is
mid 80s). These fatty acids are killers in adults, but it's certainly
possible that rapidly growing fetuses could use them.
 
On Sun, 27 Mar 2005 20:07:05 -0500, "Pizza Girl" <[email protected]> wrote:

>Yeah, when my dad caught us smoking cigarettes behind the old barn, he tore
>up the pack and made us eat them. We were sick for the erst of the day.


In case it really happened, be glad you survived. The amount of
nicotin in a single cigarette is on the limit of being a lethal dose.